Association of plasma S100A12 level with cardiovascular diseases.

2011 Fiscal Year Final Research Report

• Project/Area Number: 20590846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kansai Medical University
• Principal Investigator: KOSAKI Atsushi 関西医科大学, 医学部, 講師 (40330188)
• Co-Investigator(Kenkyū-buntansha): MORI Yasukiyo 京都府立医科大学, 医学研究科, 准教授 (40268371)
• Project Period (FY): 2008 – 2011
• Keywords: 動脈硬化 / 心血管イベント / 慢性腎臓病 / S100A12

Research Abstract

In end stage renal disease(ESRD) patients, we found that mean plasma S100A12 level was 2.3-fold higher than that in control subjects and that this level was an independent factorassociated with the prevalence of atherosclerotic cardiovascular diseases(CVD) such as ischemic heart disease including myocardial infarction and angina pectoris, symptomatic stroke and symptomatic peripheral vascular disease. Therefore, we anticipate an important role for S100A12 as a novel biomarker to predict CVD in patients with ESRD. Prospective and interventional studies are currently ongoing to further elucidate the relationship between plasma S100A12 level and CVD.

Research Products

• [Journal Article] Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease (2011)
  • Author(s): Shiotsu Y, Mori Y, Hatta T, Maki N, Iida K, Matsuoka E, Kado H, Ishida R, Kishimoto N, TamagakiK, Nishimura M, Iwamoto N, Ono T, Matsubara H, Kosaki A.
  • Journal Title: Nephron Extra Volume: 1 Pages: 242-250
  • Peer Reviewed
• [Journal Article] Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients (2011)
  • Author(s): Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, HattaT, Maki N, Iida K, Iwamoto N, Ono T, Matsuoka E, Kishimoto N, Tamagaki K, Matsubara H, Kosaki A
  • Journal Title: Clin. J. Am. Soc. Nephrol. Volume: 6 Pages: 718-723
  • Peer Reviewed
• [Journal Article] Increased plasma S100A12(EN-RAGE) levels in hemodialysis patients with atherosclerosis (2009)
  • Author(s): Mori Y, Kosaki A, Kishimoto N, Kimura T, Iida K, Fukui M, Nakajima F, Nagahara M, Urakami M, Iwasaka T, Matsubara H
  • Journal Title: Am. J. Nephrol. Volume: 29 Pages: 18-24
  • Peer Reviewed
• [Presentation] Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease (2011)
  • Author(s): Mori Y, Shiotsu Y, Matsuoka E, Kosaki A
  • Organizer: ASN's Annual Renal Week Meeting 2011
  • Place of Presentation: Philadelphia, PA. USA
  • Year and Date: 2011-11-10
• [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases in non-diabetic hemodialysis patients (2010)
  • Author(s): Mori Y, Shiotsu Y, Kosaki A
  • Organizer: ASN's Annual Renal Week Meeting 2010
  • Place of Presentation: Denver, Co. USA
  • Year and Date: 2010-11-19
• [Presentation] 血中S100A12タンパク質の動脈硬化性血管障害イベントへの関与に関する研究 (2010)
  • Author(s): 小崎篤志、森泰清
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-05-29
• [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases inhemodialysis patients (2009)
  • Author(s): Mori Y, Shiotsu Y, Nishimura M, Hatta T, Maki N, Iida K, Matsubara H, Kosaki A
  • Organizer: ASN's Annual Renal Week Meeting 2009
  • Place of Presentation: San Diego, CA. USA
  • Year and Date: 2009-10-30