2011 Fiscal Year Final Research Report
The role of oxidative stress and antioxidant dilemma in ischemic heart disease
| Project/Area Number |
20590847
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTANI Hajime 関西医科大学, 医学部, 准教授 (60168979)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 臨床心血管病態学 |
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| Research Abstract |
We have demonstrated that uncoupling of inducible nitric oxide synthase(iNOS) plays a pivotal role in cardiac dysfunction in the diabetic hearts and inhibition of iNOS uncoupling alleviate cardiac function and unmasks tolerance to ischemia/reperfusion injury in these hearts.
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