Efferocytosis as a novel therapeutic target of emphysema

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590900
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagasaki University
• Principal Investigator: MORIMOTO Konosuke Nagasaki University, 熱帯医学研究所, 准教授 (50346970)
• Project Period (FY): 2008 – 2010
• Keywords: 閉塞性肺疾患 / 炎症終息

Research Abstract

We proved the important role of receptor for advanced glycation endproducts (RAGE) in apoptotic cell clearance in inflamed lung. RAGE directly recognized phosphatidylserine on apoptotic cells and enhanced efferocytosis.
We also hypothesized MCP-1 plays crucial role in pathogenesis of chronic inflammation in lung and emphysema. We proved that MCP-1 enhances apoptotic cell clearance through Rac ? PI3K pathway in alveolar macrophages (AMs).

Research Products

• [Journal Article] Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells. (2011)
  • Author(s): He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahasi T, Yamada M, Yamaya M, Maekawa T, Yamamoto Y, Yamamoto H.
  • Journal Title: EMBO Rep. 12(4) Pages: 358-364
  • Peer Reviewed
• [Journal Article] Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation. (2010)
  • Author(s): Tanaka T, Terada M, Ariyoshi K, Morimoto K.
  • Journal Title: Biochem Biophys Res Commun. 399 Pages: 677-682
  • Peer Reviewed
• [Presentation] Production of Hepatocyte Growth Factor by Alveolar Macrophages that Have Engulfed Apoptotic Cells is Impaired in Streptozotocin-induced Diabetetic Mice. (2011)
  • Author(s): Morimoto K, Kuroki R, Yamashita Y, Tanaka T, Takaki M, Ariyoshi K, Amano H
  • Organizer: American Thoracic Society International Conference
  • Year and Date: 2011-05-14
• [Presentation] 肺の炎症巣でのアポトーシス細胞貪食除去(Efferocytosis)におけるMCP-1/CCR2の役割 (2009)
  • Author(s): 田中健之、寺田真由美、森本浩之輔、有吉紅也
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] MCP-1/CCL2 (Monocyte Chemoattractant Protein-1/CC Chemokine Ligand-2) enhance apoptotic cells removal(efferocytosis) through activation of Rac1. (2009)
  • Author(s): 田中健之, 森本浩之輔, 有吉紅也
  • Organizer: American Thoracic Society International Conference
  • Year and Date: 2009-05-18