2010 Fiscal Year Final Research Report
Generation of animal models and establishment of the drug-efficacy evaluation system in polycystic kidney disease.
| Project/Area Number |
20590940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
MOCHIZUKI Toshio Hokkaido University, 医学部, 講師 (00277120)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO Saori 北海道大学, 北海道大学病院, 助教 (90463736)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 多発性嚢胞腎 / ADPKD、PKD1、PKD2、PKD1ノックアウトマウス / トランスジェニックメダカ |
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| Research Abstract |
In this study, the efficacy evaluation system in the transgenic medaka induced by deletion mutation of Pkd2 gene was not able to be established because of the problem of the breeding. However, in interferon-inducible Pkd1 conditional knockout mice, in which interferon was started at one week after birth as an early cyst formation group, remarkable cyst formation was observed. It was possible to evaluate the efficacy of mTOR inhibitor for cystic formation in these Pkd1 conditional knockout mice. It was suggested that these mice would be one of the model animals which could perform an efficacy evaluation system for treatment in polycystic kidney diseases.
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