2010 Fiscal Year Final Research Report
To clarify the mechanism of chronic kidney disease progression by uremic toxins and its application for the treatment
| Project/Area Number |
20590974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Shimane University |
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Principal Investigator |
YANO Shozo Shimane University, 医学部, 講師 (80403450)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Toshitsugu 島根大学, 医学部, 教授 (00226458)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 尿毒素 / 終末糖化産物 / 血管平滑筋細胞 / 血管石灰化 / 血管内皮細胞 |
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| Research Abstract |
In vascular endothelial cells, one of uremic toxins, phenyl acetic acid stimulates reactive oxygen species (ROS) production and TNFα in a dose-dependent manner, and ROS inhibitor TEMPOL suppressed TNFα secretion. In vascular smooth muscle cells (VSMC), advanced glycation end-products (AGEs) stimulate NADPH oxidase activity followed by ROS generation, which may play important roles in an osteoblastic trans-differentiation from VSMC and vascular calcification.
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