2010 Fiscal Year Final Research Report
Regression of hypertension : molecular analysis and epigenetic assessment
| Project/Area Number |
20590984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
SASAMURA Hiroyuki Keio University, 医学部, 准教授 (00235293)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 高血圧 / 退行 / レニンーアンジオテンシン系 |
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| Research Abstract |
Hypertension is the most prevalent disease in Japan, and affects at least one in four of the general population. Although hypertension is considered to be a progressive, irreversible disease, we demonstrated in this study that reversal or regression of hypertension may be feasible in animal models of hypertension. Regression of hypertension was achieved by 'pulse' treatment with an angiotensin receptor blocker at 10-50 times the normal dose, by a mechanism involving reversal of renal arteriolar hypertrophy.
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