2010 Fiscal Year Final Research Report
Pathological studies on Parkinson's disease and amyotrophic lateral sclerosis
| Project/Area Number |
20591017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gunma University |
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Principal Investigator |
OKAMOTO Koichi Gunma University, 大学院・医学系研究科, 教授 (00124652)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 筋萎縮性側索硬化症 / パーキンソン病 / 前頭側頭葉変性症 / α-synuclein / TDP-43 / FUS / optineurin / peripherin |
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| Research Abstract |
In our 204 consecutive autopsied cases, there were close relationship between α-synuclein pathology in dorsal vagal nuculei and the decrease of tyrosine hydroxylase immunorectivites in cardiac sympathetic nerves. We reported FUS pathology in various amyotrophic lateral sclerosis (ALS) types, clinical and neuropathological findings of Japanese familial ALS patients with a novel TDP-43 A315E mutation, presence of several peripherin-positive Bunina bodies, and appearance of optineurin not only in ALS but also in many neurodegenerative conditions.
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[Journal Article] A Japanese ALS6 family with mutation R521C in the FUS/TLS gene : a clinical, pathological and genetic report.2010
Author(s)
Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
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Journal Title
J Neurol Sci 296(1-2)
Pages: 59-63
Peer Reviewed
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[Journal Article] TDP-43 mutation in familial amyotrophic lateral sclerosis.2008
Author(s)
Yokoseki A, Shiga A, Tan-C-F, Tagawa A, Kaneko H, Koyama A, Eguchi H, Tsujino A, Ikeuchi T, Kakita A, Okamoto K, Nishizawa M, Takahashi H, Onodera O
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Journal Title
Ann Neurol 63(4)
Pages: 538-542
Peer Reviewed
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