2010 Fiscal Year Final Research Report

Morphological analysis of neural connections of the presubicular and parasubicular areas.

Research Project

Project/Area Number	20591032
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Neurology
Research Institution	Tokyo Women's Medical University
Principal Investigator	HONDA Yoshiko Tokyo Women's Medical University, 医学部, 講師 (40287313)
Project Period (FY)	2008 – 2010
Keywords	臨床神経形態学 / 記憶
Research Abstract	The parahippocampal regions including the presubiculum are known to be responsible for processing and integrating spatial representation information. However, details of input- and output connections of these areas are still unknown. To understand better the functional roles played by the presubiculum, we studied the axonal morphology of single layer V neurons of the presubiculum, which were visualized in the rat with a viral vector expressing membrane-targeted green fluorescent protein. We found that individual layer V neurons provide axonal branches to one or two cortical areas with several recurrent collaterals to the presubiculum itself. Our data demonstrated that there are at least six types of neurons which have different patterns of axonal collateralization in layer V of the rat presubiculum.