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2010 Fiscal Year Final Research Report

development of new therapeutic approach to diabetes mellitus using human pancreatic duct cells

Research Project

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Project/Area Number 20591042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionUniversity of Tsukuba

Principal Investigator

YATOH Shigeru  University of Tsukuba, 大学院・人間総合科学研究科, 講師 (50451703)

Project Period (FY) 2008 – 2010
Keywordsインスリン / 再生医療 / 膵島
Research Abstract

We tried to induce human pancreatic duct cells into insulin-producing cells, which can be used to treat diabetic patients. Though duct cell fraction is got when islet transplantation, it is usually thrown away. As a result of our study to evaluate various factors and conditions to induce differentiation, it was suggested that glucagon-like peptide-1 (GLP-1) increased insulin-producing cells. Furthermore, expression of neurogenin-3 (ngn-3) was elevated in this process of differentiation. This result suggested that the process might mimic physiological differentiation because transient expression of ngn-3 was observed when stem/progenitor cells were induced into mature pancreatic B cells.

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Published: 2012-01-26   Modified: 2016-04-21  

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