2010 Fiscal Year Final Research Report
Molecular mechanisms of alsosterone-induced tissue injury
| Project/Area Number |
20591097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kochi University |
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Principal Investigator |
IWASAKI Yasumasa Kochi University, 教育研究部・医療学系, 教授 (30303613)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルドステロン / ミネラロコルチコイド / グルココルチコイド / ステロイド / 核内受容体 / ストレス / 転写調節 |
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| Research Abstract |
We have investigated the molecular mechanisms of aldosterone-induced tissue injury using neuronal and vascular smooth muscle cells. We found that aldosterone induced the genes related to ion-channels, Ca-regulated transcription factors, inflammation, and rennin-angiotensin system. We also found that the co-expression of gluocorticoid receptor and/or steroid receptor cofactor(s) is necessary for aldosterone/MR mediated gene transcription.
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[Journal Article] Corticotropin-releasing hormone (CRH) transgenic mice display hyperphagia with increased Agouti-related protein mRNA in the hypothalamic arcuate nucleus.2011
Author(s)
Nakayama S, Nishiyama M, Iwasaki Y, Shinahara M, Okada Y, Tsuda M, Okazaki M, Tsugita M, Taguchi T, Makino S, Stenzel-Poore MP, Hashimoto K, Terada Y.
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Journal Title
Endocr J 58
Pages: 279-286
Peer Reviewed
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[Journal Article] Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro.2009
Author(s)
Tsugita M, Iwasaki Y, Nishiyama M,, Taguchi T, Shinahara M, Taniguchi Y, Kambayashi M, Nishiyama A, Gomez-Sanchez CE, Terada Y, Hashimoto K.
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Journal Title
Mol Cell Endocrinol 302
Pages: 18-25
Peer Reviewed
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[Presentation] The target genes of aldosterone in vascular smooth muscle cells.2010
Author(s)
Tsugita M, Iwasaki Y, Nishiyama M, Taguchi T, Okazaki M, Taniguchi Y, Nakayama S, Zhao LF, Kambayashi M, Takao T, Hashimoto K, Terada Y.
Organizer
The 92th Annual Meeting of the Endocrne Society.
Place of Presentation
San Diego, USA.
Year and Date
20100619-20100622
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[Presentation] Glucocorticoid receptor play an indispensable role in mineralocorticoid receptor-dependent transcription/role of GR in MR-dependent transcription.2010
Author(s)
Tsugita M, Iwasaki Y, Nishiiyama M, Taguchi T, Shinahara M, Taniguchi Y, Okzaki M, Nakayama S, Mambayashi M, Takao T, Nishiyama A, Gomez-Sanchez EP, Hashimoto K, Terada Y.
Organizer
14^<th> International Congress of Endocrinology
Place of Presentation
Kyoto, Japan
Year and Date
20100326-20100330
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[Remarks] ホームページ等 なし
