2010 Fiscal Year Final Research Report
Calcium-sensing receptor agonist inhibits parathyroid proliferation
| Project/Area Number |
20591101
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
IMANISHI Yasuo Osaka City University, 大学院・医学研究科, 講師 (50326253)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 副甲状腺アデノーマ / 2次性副甲状腺機能亢進症 / 副甲状腺ホルモン |
|---|
| Research Abstract |
Cinacalcet HCl (Cinacalcet), a type II calcimimetic compound, suppresses PTH secretion from parathyroid cells in both primary and secondary hyperparathyroidism. Effect of cinacalcet on parathyroid cell proliferation was analyzed in a transgenic mouse model of primary hyperparathyroidism (PC2), in which parathyroid-targeted overexpression of the cyclin D1 oncogene causes chronic biochemical hyperparathyroidism and parathyroid cell hyperplasia. Cinacalcet was mixed into the rodent diet (1 mg/g) and orally administrated to 80 weeks-old PC2 mice for 10 days before sacrifice. Compared to untreated PC2 mice, cinacalcet significantly suppressed both serum calcium and PTH. The ratio of BrdU positive cells was significantly increased in untreated PC2 mice compared to wild type mice, and was significantly suppressed by cinacalcet. These data suggest that cinacalcet suppressed both serum PTH level and parathyroid cell proliferation in vivo in this model of primary hyperparathyroidism, and may in part suppress primary hyperparathyroidism by suppressing parathyroid cell proliferation.
|
-
-
-
-
-
-
-
[Journal Article] The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels2010
Author(s)
Ishii A, Imanishi Y, Kobayashi K, Hashimoto J, Ueda T, Miyauchi A, Koyano HM, Kaji H, Saito T, Oba K, Komatsu Y, Kurajoh M, Nagata Y, Goto H, Wakasa K, Sugimoto T, Miki T, Inaba M, Nishizawa Y
-
Journal Title
Calcif Tissue Int 86
Pages: 455-462
Peer Reviewed
-
-
-
[Journal Article] Osteosarcoma in a pregnant patient with McCune-Albright syndrome2009
Author(s)
Kanazawa I, Yamauchi M, Yano S, Imanishi Y, Kitazawa R, Nariai Y, Araki A, Kobayashi K, Inaba M, Maruyama R, Yamaguchi T, Sugimoto T
-
Journal Title
Peer Reviewed
-
[Journal Article] Severe hypophosphatemic osteomalacia with fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis2009
Author(s)
Bando H, Hashimoto N, Hirota Y, Sakaguchi K, Hisa I, Inoue Y, Imanishi Y, Seino S, Kaji H
-
Journal Title
Intern Med 48
Pages: 353-358
Peer Reviewed
-
-
-
-
[Journal Article] Serum Levels of TRAP5b, a New Bone Resorption Marker Unaffected by Renal Dysfunction, as a Useful Marker of Cortical Bone Loss in Hemodialysis Patients2008
Author(s)
Shidara K, Inaba M, Okuno S, Yamada S, Kumeda Y, Imanishi Y, Yamakawa T, Ishimura E, Nishizawa Y
-
Journal Title
Calcif Tissue Int 82
Pages: 278-287
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
