2010 Fiscal Year Final Research Report
Study on energy storage mechanism of ghrelin using transgenic rats whose ghrelin receptor is suppressed
| Project/Area Number |
20591103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SHIBASAKI TAmotsu Nippon Medical School, 大学院・医学研究科, 教授 (00147399)
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| Co-Investigator(Kenkyū-buntansha) |
MANO Asuka 日本医科大学, 医学部, 講師 (50343588)
NEMOTO Takahiro 日本医科大学, 医学部, 講師 (40366654)
OHATA Hisayuki 日本医科大学, 医学部, 助教 (80256924)
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| Project Period (FY) |
2008 – 2010
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| Keywords | グレリン / グレリン受容体 / 体脂肪 / エネルギー代謝 |
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| Research Abstract |
Transgenic rats expressing an antisense against ghrelin receptor mRNA show reduced adipose tissue. However, it was not clear whether ghrelin is involved in an increase in body fat during aging. This study showed that the inhibitory action of ghrelin on brown adipose tissue increases with aging and that the dorsal medial hypothalamus is involved in its action in rats.
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