2010 Fiscal Year Final Research Report
Development of antibody-conjugatedβ-catenin siRNA therapy against multiple myeloma
| Project/Area Number |
20591121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
ASHIHARA Eishi Kyoto University, 医学研究科, 講師 (70275197)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Taira 京都大学, 大学院・医学研究科, 教授 (80229286)
KIMURA Shinya 佐賀大学, 医学部, 教授 (80359794)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMAZAKI Chihiro 京都府立医科大学, 大学院・医学研究科, 講師 (50170931)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 多発性骨髄腫 / siRNA / β-catenin / CD138 / RNA干渉 / 分子標的 |
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| Research Abstract |
β-catenin silencing is explored as a novel therapeutic target against multiple myeloma (MM). β-catenin protein is overexpressed in human MM cell lines as well as CD138-positive MM cells obtained from patients. The treatment of β-catenin siRNA with atelocollagen significantly inhibited the proliferation of MM cells in a MM-bearing mouse model. Furthermore, we have developed antibody-conjugated oligo-RNAs. It is suggested that these findings will enable to develop siRNA drugs against MM in the near future.
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[Journal Article] A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro.2010
Author(s)
Kawata E, Ashihara E, Nakagawa Y, Kiuchi T, Ogura M, Yao H, Sakai K, Tanaka R, Nagao R, Yokota A, Takeuchi M, Kimura S, Hirai H, Maekawa T.
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Journal Title
Cancer Lett 294
Pages: 245-253
Peer Reviewed
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[Journal Article] Anti-myeloma activity of modified galectin-9 through JNK and p38 MAPK pathways.2010
Author(s)
Kobayashi T, Kuroda J, Ashihara E, Terui Y, Oomizu S, Yamamoto M, Taniyama A, Matsumoto Y, Horiike S, Hatake K, Yamauchi A, Hirashima M, Taniwaki F.
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Journal Title
Leukemia 24
Pages: 843-850
Peer Reviewed
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[Journal Article] β-catenin siRNA successfully suppressed progression of multiple myeloma in a mouse model.2009
Author(s)
Ashihara E, Kawata E, Nakagawa Y, Shimazaki C, Kuroda J, Taniguchi T, Uchiyama H, Tanaka R, Yokota A, Takeuchi M, Kamitsuji Y, Inaba T, Taniwaki M, Kimura S, Maekawa T
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Journal Title
Clin Cancer Res 15
Pages: 2731-2738
Peer Reviewed
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[Journal Article] JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation co-exits, but originate from separate clones.2008
Author(s)
Kuroda J, Matsumoto Y, Tanaka R, Kurita K, Kobayashi T, Shimizu D, Kimura S, Shimazaki C, Horiike S, Shimazaki C, Taniwaki M.
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Journal Title
Acta Haematol 120
Pages: 177-181
Peer Reviewed
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[Journal Article] Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin.2008
Author(s)
Kuroda J, Kamitsuji Y, Kimura S, Ashihara E, Kawata E, Nakagawa Y, Takeuichi M, Murotani Y, Yokota A, Tanaka R, Andreeff M, Taniwaki M, Maekawa T.
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Journal Title
Int J Hematol 87
Pages: 507-515
Peer Reviewed
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[Journal Article] Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer.2008
Author(s)
Kawata E, Ashihara E, Kimura S, Takenaka K, Sato K, Tanaka R, Yokota A, Kamitsuji Y, Takeuchi M, Kuroda J, Tanaka F, Yoshikawa T, Maekawa T.
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Journal Title
Mol Cancer Ther 7
Pages: 2904-2912
Peer Reviewed
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[Presentation] AV-65, a Novel inhibitor of the Wnt/β-catenin signaling pathway, inhibits the proliferation of myeloma cells.2009
Author(s)
Yao H, Ashihara E, Nagao R, Kimura S, Hirai H, Strovel JW, Padia J, Cholody WM, Maekawa T
Organizer
The 51st American Society of Hematology Annual Meeting and Exposition
Place of Presentation
New Orleans, USA.
Year and Date
20091205-20091208
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