2010 Fiscal Year Final Research Report
Functional analysis of novel effectors correlated with allergic diseases
| Project/Area Number |
20591188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
IZUHARA Kenji Saga University, 医学部, 教授 (00270463)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Shoichiro 佐賀大学, 医学部, 助教 (20346886)
KANAJI Sachiko 佐賀大学, 医学部, 助教 (50363429)
SHIRAISHI Hiroshi 佐賀大学, 医学部, 助教 (80452837)
ARIMA Kazuhiko 佐賀大学, 医学部, 講師 (60336112)
SUZUKI Shoichi 佐賀大学, 医学部, 助教 (40253695)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アレルギー・ぜんそく / 遺伝子 / 蛋白質 / 免疫学 |
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| Research Abstract |
It is known that IL-13, one of Th2-type cytokines, is important for the pathogenesis of bronchial asthma. In this study, we found the signals via Toll-like 4 receptor inhibit IL-13 production, how IL-13 interacts with its receptor, and IL-13 evokes allergic inflammation via pendrin, an anion transporter. We could show the detailed mechanism of how IL-13 causes bronchial asthma by these results.
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[Journal Article] Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma2011
Author(s)
Fujimoto K, Kawaguchi T, Nakashima O, Ono J, Ohta S, Kawaguchi A, Tonan T, Ohshima K, Yano H, Hayabuchi N, Izuhara K,Sata M
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Journal Title
Oncol Rep Vol.25, No.5
Pages: 1211-1216
Peer Reviewed
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[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
Author(s)
Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K
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Journal Title
Int Immunol Vol.22, No.9
Pages: 739-747
Peer Reviewed
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[Journal Article] The mechanism of mucus production in bronchial asthma2009
Author(s)
Izuhara K, Ohta S, Shiraishi H, Suzuki S, Taniguchi K, Toda S, Tanabe T, Yasuo M, Kubo K, Hoshino T, Aizawa H
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Journal Title
Curr Med Chem Vol.16, No.22
Pages: 2867-2875
Peer Reviewed
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[Journal Article] Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness2009
Author(s)
Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G,Tamada T Honjo E, Garcia KC,Kuroki R, Izuhara K
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Journal Title
J Biol Chem Vol.284, No.36
Pages: 24289-24296
Peer Reviewed
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[Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency2009
Author(s)
Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okumura T, Nagumo F, Ohta S, Izuhara K
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Journal Title
Int J Haematol Vol.89
Pages: 71-75
Peer Reviewed
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[Journal Article] Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease2008
Author(s)
Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K
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Journal Title
J Immunol Vol.180, No.9
Pages: 6262-6269
Peer Reviewed
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[Journal Article] Periostin and bone marrow fibrosis2008
Author(s)
Oku E, Kanaji T, Tanaka Y, Ohshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K, Yakushiji K, Yoshimoto K, Ogata H, Hamada H, Izuhara K, Sata M, Okumura T
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Journal Title
Int J Hematol Vol.88
Pages: 57-63
Peer Reviewed
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[Journal Article] A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells2008
Author(s)
Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S
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Journal Title
Endocrinology Vol.149, No.10
Pages: 4794-4798
Peer Reviewed
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