2010 Fiscal Year Final Research Report
The role of melanoma differentiation associated gene-5 in enteroviruses infection.
| Project/Area Number |
20591211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
UKIMURA Akira Osaka Medical College, 医学部, 教授 (50257862)
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| Co-Investigator(Kenkyū-buntansha) |
YASUSHI Kitaura 大阪医科大学, 名誉教授 (50084950)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コクサッキーウイルス |
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| Research Abstract |
Enteroviruses (EV) have been implicated in the pathogenesis of DCM and myocarditis. MDA-5 expression increased in cultured cells infected with coxsakievirus B3(CVB3). Expression of mRNA of MDA5, IL-6 and IFN-γ increased in murine heart tissues infected with CVB3, and the ratio of MDA-5/RIG-I also increased. MDA-5 mRNA expression in the myocardium of EV-Positive-DCM patients is significantly higher than EV-Negative-DCM patients. The ratio of MDA-5/RIG-I in the myocardium of EV-Positive-DCM patients is significantly higher than EV-Negative-DCM patients. MDA-5 mRNA over expression or increased MDA-5/RIG-I ratio should be a marker of active replication of EV infection in DCM patients.
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[Journal Article] Effects of acarbose on the acceleration of postprandial hyperglycemia-induced pathological changes induced by intermittent hypoxia in lean mice.2010
Author(s)
Miyamura M, Schnell O, Yamashita C, Yoshioka T, Matsumoto C, Mori T, Ukimura A, Kitaura Y, Matsumura Y, Ishizaka N, Hayashi T
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Journal Title
J Pharmacol Sci. 114(1)
Pages: 32-40
Peer Reviewed
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[Journal Article] Efficacy of olmesartan andnifedipine on recurrent hypoxiainduced left ventricular remodeling in diabetic mice.2010
Author(s)
Yamashita C, Hayashi T, Mori T, Matsumoto C, Kitada K, Miyamura M, Sohmiya K, Ukimura A, Okada Y, Yoshioka T, Kitaura Y, Matsumura Y
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Journal Title
Life Sci. 86(9-10)
Pages: 322-30
Peer Reviewed
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[Journal Article] Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice.2009
Author(s)
Matsumoto C, Hayashi T, Kitada K, Yamashita C, Miyamura M, Mori T, Ukimura A, Ohkita M, Jin D, Takai S, Miyazaki M, Okada Y, Kitaura Y, Matsumura Y
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Journal Title
Hypertension. 54(1)
Pages: 164-71
Peer Reviewed
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[Journal Article] Enhanced expression of type 1 helper T-cell cytokines in the myocardium of active cardiac sarcoidosis.2008
Author(s)
Terasaki F, Ukimura A, Tsukada B, Fujita S, Katashima T, Otsuka K, Otsuka K, Kanzaki Y, Shimomura H, Fujita M, Tanaka T, Kitaura Y, Circ J
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Journal Title
Peer Reviewed
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