2010 Fiscal Year Final Research Report
Research of new biomarkers of childhood acute encephalopathy associated with infection
| Project/Area Number |
20591225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
TORISU Hiroyuki Kyushu University, 大学病院, 助教 (10398076)
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| Co-Investigator(Kenkyū-buntansha) |
KIRA Ryutaro 九州大学, 大学病院, 特別教員 (70304805)
SANEFUJI Masafumi 九州大学, 大学病院, 助教 (50467940)
ISHIZAKI Yoshito 九州大学, 大学病院, 助教 (20572944)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経科学 / 免疫学 / 脳神経疾患 / 感染症 / 小児科学 |
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| Research Abstract |
To improve the prognosis of childhood acute encephalopathy associated with infection, accurate assessments followed by intensive treatments are needed at the early stage of the disease. We noticed that all patients with remarkable elevation of urinary corrected β2-microglobulin(cBMG) at the early stage had the severest neurological impairment or died. The research of the relationship between urinary cBMG at the early stage and neurological prognosis showed that the urinary cBMG of patients with the severest neurological impairment including death was statistically higher than that of recovered patients. Urinary cBMG could be a readily-measurable biomarker for the evaluation of childhood acute encephalopathy associated with infection.
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Research Products
(23 results)
