2012 Fiscal Year Final Research Report
Diagnosis and stem cell transplantation for inherited bone marrow failure syndrome
| Project/Area Number |
20591262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokai University |
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Principal Investigator |
YABE Miharu 東海大学, 医学部, 准教授 (40172514)
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| Co-Investigator(Kenkyū-buntansha) |
YABE Hiromasa 東海大学, 医学部, 准教授 (70220217)
KATO Shunichi 東海大学, 医学部, 教授 (70096212)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 先天性骨髄不全 / 造血細胞移植 / Fanconi貧血 / 遺伝子診断 / 発癌 / 妊孕能 |
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| Research Abstract |
Before March 2013, we studied 213 patients with bone marrow failure, and 95 were diagnosed as Fanconi anemia (FA) by chromosome instability and/or genetic subtypes. There were 41 congenital bone marrow failure syndrome (CBMFS) excluded FA and five had Diamond-Blackfan anemia. Three had dyskeratosis congenital and other 31 were unclassifiable CBMFS. Eighty-nine FA patients and 27 patients with CBMFS received stem cell transplantation. Significant advances have been made in the use of fludarabine-based conditioning regimen for both patients with FA and CBMFS.
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Research Products
(17 results)
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[Journal Article] Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism2012
Author(s)
Yabe M, Shimizu T, Morimoto T, Koike T, Takakura H, Tsukamoto H, Muroi K, Oshima K, Asami K, Takata M, Yamashita T, Kato Sand Yabe H
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Journal Title
Pediatric Transplant
Volume: 16
Pages: 340-345
Peer Reviewed
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[Journal Article] Successful allo-HSCT with a minimal myeloablative conditioning regimen in an adult patient with Fanconi's anemia2012
Author(s)
Maekawa K, Yoshimitu M, Fujiwara H, Matsushita K, Kawada H, Hamada H, Suzuki S, Uozumi K, Ohtsuka M, Hanada S, Yabe M, Yab e H and Arima N
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Journal Title
Bone Marrow Transplantation
Volume: 47
Pages: 159-160
Peer Reviewed
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[Journal Article] Decreased serum testosterone levels in long-term adult survivors with fatty liver after childhood stem cell transplant2012
Author(s)
Hyodo H, Ishiguro H, Tomita Y, Takakura h, Koike T, Shimizu T, Morimoto T, Yabe H, Yabe M, Kojima SI, Shiraishi k, Minemura T and Kato S.
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Journal Title
Biol Blood Marrow Transplant
Volume: 18
Pages: 1090-1098
Peer Reviewed
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[Journal Article] High incidence of fatty liver and insulin resistance in long-term adult survivors of childhood SCT2011
Author(s)
Tomita Y, Ishiguro H, Yasuda Y, Hyodo H, Koike T, Shimizu T, Morimoto T, Hattori K, Matsumoto M, Inoue H, Yabe H, Yabe M, Shinohara O, Minemura T and Kato S.
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Journal Title
Bone Marrow Transplantation
Volume: 46
Pages: 416-425
Peer Reviewed
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[Journal Article] Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients2010
Author(s)
abhan SK, Bitencourt M, Duval M, Abecasis M, Dufour C, Boudjedir K, Rocha V, Socie' G, Passweg J, Goi K, Sanders J, Snowden J, Yabe H, Pasquini R, Gluckman E
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Journal Title
Haematologica
Volume: 95
Pages: 1783-1787
Peer Reviewed
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[Presentation] Hematopoietic stem cell transplantation for Fanconi Anemia patients in Japan: An analysis of the registry data2012
Author(s)
Yabe M, Takahashi Y, Inagaki J, Koh K, Endo M, Kawa K, Kato K, Sakamaki H, Atsuta Y, Yabe H
Organizer
24th Annual Fanconi Anemia Research Fund Scientific Symposium
Place of Presentation
Denver, USA
Year and Date
20120900
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[Presentation] A fludarabine-based conditioning for alternative donor haematopoietic stem cell transplantation in inherited bone marrow failure syndrome2012
Author(s)
M Yabe, H Yabe, T Shimizu, T Morimoto, T Koike, H Takakura, K Ohtsubo, A Fukumura, T Morimoto, H Yoshida, Y Ohtsuka, M Shiomi, S Kato.
Organizer
38thAnnual Meeting of the European Group for Blood and Marrow Transplantation
Place of Presentation
Geneva
Year and Date
20120800
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