2010 Fiscal Year Final Research Report
Research on Molecular Target therapy for Acral Melanoma
| Project/Area Number |
20591318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
MURATA Hiroshi Shinshu University, 医学部, 助教 (70262722)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Minoru 岡山大学, 医歯(薬)学総合研究科, 非常勤研究員 (20154784)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 悪性黒色腫 / 末梢血循環腫瘍細胞 / BRAF変異検査 / KIT遺伝子変異検査 / 個別化治療 / 薬剤耐性機序 / 腫瘍細胞の多様性 |
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| Research Abstract |
To personalize the therapy with molecular targeting therapy for melanoma, we showed that : 1. two of 28 case had activating mutation of KIT gene and one of these mutation, D820Y, was sensitive to the sunitinib. 2. Circulating melanoma cells could extract by using anti-HMW-MAA antibody and we detect the BRAF mutation states from them. 3. We showed polyclonality of melanoma cells on BRAF mutation states.
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[Journal Article] NADPH oxidase (Nox) 4 contribute to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression.2009
Author(s)
Yamaura M, Mitsushita J, Furuta S, Kiniwa Y, Ashida A, Goto Y, Shang WH, Kubodera M, Kato M, Takata M, Saida T, Kamata T
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Journal Title
Cancer Res 69
Pages: 2647-2654
Peer Reviewed
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