2010 Fiscal Year Final Research Report
The role of Toll-like receptor signaling in wound healing
| Project/Area Number |
20591355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
TSUBOI Ryoji Tokyo Medical University, 医学部, 主任教授 (70221421)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Masukichi 東京医科大学, 医学部, 助教 (30366124)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 創傷治癒 / Toll様受容体 / TLRシグナル / 遺伝子欠損マウス / 創傷治癒遅延モデル / コラーゲンゲル収縮 / ピルフェニドン / FGF-7ファミリー |
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| Research Abstract |
Although Toll-like Receptor (TLR) plays an important role in innate immunity, its role in wound healing has yet to be analyzed. In the present study, the healing process of dermal wounds in TLR knock-out mice was examined. No significant findings were observed in Myd88 KO mice. Meanwhile, PDLIM2 KO mice, which showed exaggerated NF-κB activity, demonstrated earlier wound closure due to enhanced wound contraction. Contraction of the collagen gel seeded with fibroblasts from KO mice was also enhanced, suggesting the involvement of TLR signaling in wound healing.
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