2010 Fiscal Year Final Research Report

Physiology and application of deimination of humnan hair follicle S100A3

Research Project

Project/Area Number	20591358
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dermatology
Research Institution	Kinki University
Principal Investigator	KAWADA Akira Kinki University, 医学部, 教授 (90160986)
Co-Investigator(Kenkyū-buntansha)	TAKAHARA Hidenari 茨城大学, 農学部, 教授 (30122063)
Project Period (FY)	2008 – 2010
Keywords	S100A3,脱イミノ化反応 / ヒト毛嚢 / peptidylarginine deimase / 線構造解析 / カルシウム結合タンパク質
Research Abstract	S100A3 protein specifically expressed in the cuticular cells of hair follicle. Human S100A3 is characterized by two disulphide bridges, a preformed Zn^<2+>-binding site, and a specific citrullination site by deimination. Conversion to the citrulline residues, symmetrically located on the S100A3 dimer plane-causes the assembly of the Ca^<2+>-bound S100A3 homotetramer. S100A3 acts as a Ca^<2+> buffering protein providing Ca^<2+> ions in turn to the deimination.

(4 results)