2010 Fiscal Year Final Research Report
Cognitive dysfunction, brain structural abnormality and molecular biological vulnerability in schizophrenia
| Project/Area Number |
20591375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
HIRAYASU Yoshio Yokohama City University, 医学研究科, 教授 (70244324)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWANISHI Chiaki 横浜市立大学, 医学部, 准教授 (50315769)
KATO Daiji 横浜市立大学, 附属病院, 助教 (70363819)
NAKAMURA Motoaki 横浜市立大学, 医学研究科, 客員研究員 (50464532)
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| Research Collaborator |
HAYANO Fumi 横浜市立大学, 医学研究科, 特任助教 (90573527)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床精神分子遺伝学 / 神経画像 |
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| Research Abstract |
One hundred and one patients (male:female=39:62) with schizophrenia over 18 years old underwent MRI scans in this study. The patterns of age-related volumes changes in the whole brain gray matter, white matter and cerebrospinal fluid were estimated using MRI volumetry. Brain regions with volume reduction related to disease-specific cognitive dysfunction was also shown. In addition, the type II group of Orbito-Frontal Cortex (OFC) sulcogyral pattern with BDNF Val/Val genotype was a significant small population compared with other type groups in schizophrenia. The BDNF genotype may partially provide the OFC sulcogyral formation and involve the development in schizophrenia.
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Research Products
(18 results)
