2010 Fiscal Year Final Research Report
Role of neuroplastin in memory impairment in schizophrenia-A basic and clinical study
| Project/Area Number |
20591377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
AKIYAMA Kazufumi Dokkyo Medical University, 医学部, 教授 (40150990)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Atsushi 獨協医科大学, 医学部, 助教 (00453407)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 統合失調症 / ニューロプラスチン / 記憶障害 / 認知機能 |
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| Research Abstract |
We investigated whether variations in single nucleotide polymorphism (SNPs) in 5,-upstream regions of genes encoding neuroplastin (NPTN) confer cognitive and memory function in schizophrenia. Subjects consisting of 207 schizophrenic patients and 262 unrelated control subjects were administered BACS-J, and a proxy measure of premorbid IQ by using Japanese Adult Reading Test. Patients performed significantly below controls on all domains of BACS-J. There was no effect of rs3840846 on any domain of BACS-J. Only in patients, but not controls, rs3826047 A/G carriers performed significantly worse in executive function than G/G carriers. Only in patients, but not controls, rs3743500 G/G carriers performed significantly worse in word memory and word fluency than G/T carriers. These data suggest that putative promoter region of the NPTN gene may be involved in impairment of word memory and executive function in schizophrenia.
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