2010 Fiscal Year Final Research Report
Anti-inflammatory effects on amyloid vaccination therapy by NSAID : a development of Alzheimer disease therapy
| Project/Area Number |
20591406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
MORIHARA Takashi Osaka University, 医学系研究科, 助教 (90403196)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Masatoshi 大阪大学, 医学系研究科, 教授 (00179649)
KUDO Takashi 大阪大学, 医学系研究科, 准教授 (10273632)
TANAKA Toshihisa 大阪大学, 医学系研究科, 講師 (10294068)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルツハイマー病 / NSAID / 遺伝子 / アミロイドβ蛋白 / モデル動物 |
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| Research Abstract |
The suppression of Abea42 production by modified NSAIDs was not observed. APP Tg mice with mixed genetic background was reliable tool for the screening of the genes which modify the Abeta accumulation in brain. Candidate gene approaches have shown that no inflammation related gene associated with Abeta accumulation in our mice. CRP levels in elderly persons did not associate with the cognitive decline.
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