In vivo study to utilize Positron Emission Tomography for evaluating the indication and efficacy of molecular targeted agents.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591433
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yamagata University
• Principal Investigator: YOSHIOKA Takashi Yamagata University, 医学部, 教授 (90271981)
• Co-Investigator(Kenkyū-buntansha): FUKUDA Hiroshi 東北大学, 加齢医学研究所, 教授 (30125645) ; FURUMOTO Syozou 東北大学, 大学院・医学系研究科, 准教授 (00375198)
• Project Period (FY): 2008 – 2010
• Keywords: ポジトロントレーサー / 分子標的治療 / 治療効果判定

Research Abstract

To examine the possibility of rapid evaluation about treatment effects of molecular targeted agents by positron emission tomography, the accumulation of 2-deoxy-2[18F]fluoro-D-glucose (FDG) on tumors treated by the anti-neovazcular agent, Bevacizumab, was measured, using COLO205 that was human xenograft transplanted into nude mice. Although Bevacizmab suppressed the growth of tumors, the accumulation of FDG on tumors was increased. It was thought that new tracers should be developed to evaluate the efficacy of each molecular targeted agent.

Research Products

• [Journal Article] 腫瘍増大に伴い化学療法を変更し4年以上の長期生存を得られている同時性多発肝転移のStageIV胃癌の1例 (2010)
  • Author(s): 安藤敏典、鈴木祥郎、菅野伸一、宮下英士、田中直樹、生澤史江、柴田近、佐々木巌、吉岡孝志
  • Journal Title: 癌と化学療法 37 Pages: 891-894
  • Peer Reviewed
• [Journal Article] Phase I/II study of sequential therapy with irinotecan and S-1 for metastatic colorectal cancer. (2009)
  • Author(s): Yoshioka T, Kato S, Gamoh M, Chiba N, Suzuki T, Sakayori N, Kato S, Shibata H, Shimodaira H, Otsuka K, Kakudo Y, Takahashi S, Ishioka C
  • Journal Title: British Journal of cancer 101 Pages: 1972-1977
  • Peer Reviewed
• [Journal Article] Prospective comparison of surgery alone and chemoradiotherapy with selective surgery in resectable squamous cell carcinoma of the esophagus. (2009)
  • Author(s): Ariga H, Nemoto K, Miyazaki S, Yoshioka T, Ogawa Y, Sakayauchi T, Jingu K, Miyata G, Onodera K, Ichikawa H, Kamei T, Kato S, Ishioka C, Satomi S, Yamada S
  • Journal Title: International Journal of Radiation Oncology Biology Physics 75 Pages: 348-356
  • Peer Reviewed
• [Journal Article] 18FDG uptake associated with CT density on PET/CT in lungs with and without chronic interstitial lung disease. (2009)
  • Author(s): Inoue K, Okada K, Taki Y, Goto R, Kinomura S, Fukuda H
  • Journal Title: Annals Nuclear Medicine 23 Pages: 277-281
  • Peer Reviewed
• [Journal Article] Increase of serum CA 19-9 level without an evident lesion on conventional imaging is insufficient for justification of 18FDG-PET examination. (2008)
  • Author(s): Inoue K, Okada K, Taki Y, Goto R, Kinimura S, Kaneta T, Fukuda H
  • Journal Title: Hepato-Gastroenterology 55 Pages: 46-49
  • Peer Reviewed
• [Presentation] がん疼痛緩和に対する患者満足度について-山形県がん診療連携協議会緩和ケア部会調査- (2010)
  • Author(s): 吉岡孝志, 他
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-30
• [Presentation] Synthesis and preliminary evaluation of [18F]FDM for tumor imaging. (2009)
  • Author(s): Furumoto S, et al
  • Organizer: 18th Int.Symp.Radiopharm.Sci.
  • Place of Presentation: Edomonton
  • Year and Date: 2009-07-13
• [Presentation] Phase I/II study of sequential combination with irinotecan and S-1 in patients with metastatic colorectal cancer. (2008)
  • Author(s): 吉岡孝志, et al
  • Organizer: Annual meeting of American Society of Clinical Oncology
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2008-06-01