2011 Fiscal Year Final Research Report
Evaluation of radiotoxicity to lymphocytes after Yttrium-90-labelled monoclonal anti-CD20 antibody therapy
| Project/Area Number |
20591435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KINUYA Seigo 金沢大学, 医学部, 教授 (20281024)
OGAWA Shinichi 富山大学, 大学病院, 助教 (60377265)
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| Project Period (FY) |
2008 – 2011
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| Keywords | イットリウム90 / 標識抗体治療 / リンパ球 / 放射性組織障害 / 小核試験 |
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| Research Abstract |
The purpose of our study was to evaluate the degree of radiotoxicity to lymphocytes in malignant lymphoma after Y-90 therapy usingγ-H2AX foci immunodetection. This study focused on a patient who underwent Y-90 therapy for malignant lymphoma. Venous blood samples were collected from each patient. Lymphocytes were isolated from the blood samples and subjected toγ-H2AX immunofluorescence staining. The number of foci per lymphocyte nucleus was increased after Y-90 therapy.γ-H2AX foci immunodetection in lymphocytes may detect radiation-induced DNA damage associated with Y-90 therapy of malignant lymphoma.
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