2010 Fiscal Year Final Research Report
Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA) : evaluation with proton magnetic resonance spectroscopy at 3T
| Project/Area Number |
20591466
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
KOROGI Yukunori University of Occupational and Environmental Health, Japan, 医学部, 教授 (60195691)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHNARI Norihiro 産業医科大学, 医学部, 助教 (20233207)
KAKEDA Shingo 産業医科大学, 医学部, 講師 (30352313)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 3T MRI / プロトンMRスペクトロスコピー / γ-アミノ酪酸 / グルタミン酸 / 慢性疲労 / 交代制勤務 |
|---|
| Research Abstract |
Working conditions such as shift work constitute a well-known risk factor for insomnia and excessive daytime sleepiness complaints. We compared brain gamma-aminobutyric acid (GABA), glutamic acid (Glu), glutamine (Gln), and Glx (Glu+Gln) levels in day-shift versus alternate-shift workers with proton magnetic resonance spectroscopy (1H-MRS) at 3T. The study population consisted of 32 healthy adult volunteers (16 day-shift and 16 alternate-shift workers). Each subject underwent MRS conducted using a MEGA-PRESS sequence in the early morning and early evening on the same day. Spectroscopy voxels (3.0 cm×3.0 cm×3.0 cm) were placed in the frontal lobe and parieto-occipital lobe. The GABA/Cr ratio in the frontal lobe was significantly lower for the alternate-shift group than for the day-shift group in the early evening (1.885 vs. 0.875). For the other metabolite ratios (Gln/Cr andGlx/Cr), therewere no significant differences between the two groups regardless of morning or evening schedule. Our preliminary finding represents a possible alteration of GABA content in the brain related to an irregular work schedule.
|
