How much can reduction of contrast agent is possible in angiography?

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591471
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUSHITA Shonosuke University of Tsukuba, 大学院・人間総合科学研究科, 講師 (70359579)
• Co-Investigator(Kenkyū-buntansha): SAKAKIBARA Yuzuru 筑波大学, 大学院・人間総合科学研究科, 教授 (60192085) ; HYODO Kazuyuki 高エネルギー加速器研究機構, 物質構造科学研究所, 講師 (60201729)
• Project Period (FY): 2008 – 2010
• Keywords: HARP受像管 / ラット / 単色X線 / 希釈造影剤 / 放射光 / 血管造影 / 造影剤 / 造影剤腎症

Research Abstract

Contrast material is essentially employed in angiography. Contrast material-induced nephropathy (CIN) is developed in dose-dependence manner. Recently, the doses of contrast material in angiography tend to increase due to frequent application of stent therapy. On the other hand, the its dose is limited for the preservation of renal function. To solve this, we thought that the combination of synchrotron radiation angiography and high sensitive HARP receiver may make it possible to reduce the dose of contrast material. In vitro examination, synchrotron radiation angiography with HARP receiver was able to identify 2% concentration of iodine contained contrast material. In vivo examination using rat angiography in lower extremity, 8% concentration of contrast material was statistically equivalent to 32% concentration of contrast material in counting the number of vascular branches. It means that a quarter of concentration in contrast material can be effectively used, if this proposed angiographic system is utilized.

Research Products

• [Journal Article] Examination of a new angiographic system with a highly sensitive receiver and synchrotron radiation for reducing the dose of contrast medium. (2011)
  • Author(s): Konishi T, Matsushita S, Hyodo K, Aikawa S, Tokunaga C, Enomoto Y, Kanemoto S, Sato F, Hiramatsu Y, Sakakibara Y
  • Journal Title: American Journal of Roentgenology (in press)
  • Peer Reviewed
• [Journal Article] Development of FOP-HARP imaging device. Sensors, Cameras, and Systems for Industrial/Scientific Applications XI (2010)
  • Author(s): Miyakawa K, Ohkawa Y, Matsubara T, Kikuchi K, Suzuki S, Tanioka K, Kubota M, Egami N, Atsumi T, Matsushita S, Konishi T, Sakakibara Y, Hyodo K, Katori Y, Okamoto Y
  • Journal Title: Proc. of SPIE-IS&T Electronic Imaging(edited by Erik Bodegom)(Valerie Nguyen) SPIE Vol.7536 Pages: 753604-1-753604-8
  • Peer Reviewed
• [Journal Article] Erythropoietin enhances arterioles more significantly than it does capillaries in an infarct rat heart model. (2009)
  • Author(s): Imazuru T, Matsushita S, Hyodo K, Tokunaga C, Kanemoto S, Enomoto Y, Watanabe Y, Hiramatsu Y, Sakakibara Y
  • Journal Title: Int Heart J 50(6) Pages: 801-810
  • Peer Reviewed
• [Journal Article] Sex difference in peripheral arterial response to cold exposure. (2008)
  • Author(s): Sato F, Matsushita S, Hyodo K, Akishima S, Imazuru T, Tokunaga C, Enomoto Y, Kanemoto S, Hiramatsu U, Shigeta O, Sakakibara Y
  • Journal Title: Circ J 72 Pages: 1367-1372
  • Peer Reviewed
• [Presentation] Development of FOP-HARP imaging device. (2010)
  • Author(s): Miyakawa K, Ohkawa Y, Matsubara T, Kikuchi K, Suzuki S, Tanioka K, Kubota M, Egami N, Atsumi T, Matsushita S, Konishi T, Sakakibara Y, Hyodo K, Katori Y
  • Organizer: SPIE2010
  • Place of Presentation: San Jose, CA, U.S.A.
  • Year and Date: 2010-01-16
• [Presentation] 放射光と高感度受像管を用いた新しい血管造影検査システムによる造影剤使用量低減の試み (2009)
  • Author(s): 小西泰介、松下昌之助、兵藤一行、徳永千穂、佐々木昭暢、榎本佳治、金本真也、佐藤藤夫、平松祐司、榊原謙
  • Organizer: 第50回日本脈管学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-30
• [Presentation] FOP-HARP撮像管とその医療応用 (2009)
  • Author(s): 宮川和典、大川裕司、松原智樹、菊地健司、鈴木四郎、谷岡健吉、久保田節、江上典文、渥美卓治、松下昌之助、小西泰介、榊原謙、兵藤一行
  • Organizer: 2009年映像情報メディア学会年次大会
  • Place of Presentation: 東京
  • Year and Date: 2009-08-28
• [Presentation] Can angiography with synchrotron radiation and a high sensitivity receiver make lower doses of contrast material possible? (2008)
  • Author(s): Konishi T, Matsushita S, Hyodo K, Tokunaga C, Enomoto Y, Kanemoto K, Watanabe Y, Hiramatsu Y, Sakakibara Y
  • Organizer: American Heart Association, Scientific Sessions 2008
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2008-11-09