2010 Fiscal Year Final Research Report
Elucidation of the mechanism for radioresistance from the viewpoint of gap junction using 3D-cultured cancer cells
| Project/Area Number |
20591500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MITSUDOU Kenji 横浜市立大学, 医学部, 准教授 (70303641)
CHIKUMARU Hiroshi 横浜市立大学, 医学部, 助教 (80217231)
OHTA Shinsuke 横浜市立大学, 医学研究科, 客員研究員 (30336581)
ADACHI Makoto 横浜市立大学, 附属病院, 指導診療医 (10468192)
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| Project Period (FY) |
2008 – 2010
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| Keywords | がん / 培養細胞 / ギャップ結合 / 放射線 / 抵抗性 |
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| Research Abstract |
Since both HSC4 and CAL27, head and neck cancer cell lines, expressed connexin43 mRNA but exhibit no expression at protein level, hypofunction of gap junction was speculated. In another experiment, OSC-19 and HSC-3 cell lines showed decreased IR sensitivity under hypoxic culture condition, but no significant change in connexin43 protein. No obvious relationship was revealed between connexin43 and IR sensitivity in used cell lines.
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