Effects of selective bone marrow cells transplantation

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Asahikawa Medical College
• Principal Investigator: INAGAKI Mitsuhiro Asahikawa Medical College, 医学部, 非常勤講師 (80261410)
• Co-Investigator(Kenkyū-buntansha): OGAWA Katsuhiro 旭川医科大学, 医学部, 名誉教授 (50045514)
• Project Period (FY): 2008 – 2010
• Keywords: 移植外科学

Research Abstract

The therapeutic effects of bone marrow and hepatocyte transplantation were investigated regarding the treatment of retrorsine-partial hepatectomy-induced liver injury. Analbuminemic F344alb rats were given 2 doses of retrorsine 2 wk apart, followed 4 wk later by transplantation with F344 rat bone marrow cells or hepatocytes immediately after a two-thirds hepatectomy. Both bone marrow and isolated hepatocytes transplantation into the liver could prevent acute hepatic injury, conceivably due to a paracrine mechanism.

Research Products

• [Journal Article] Effects of bone marrow and hepatocytes transplantation on liver injury (2009)
  • Author(s): B.Zhang, M.Inagaki, B.Jiang, M.Miyakoshi, J.Arikura, K.Ogawa, S.Kasai
  • Journal Title: Journal of Surgical Research 157 Pages: 71-80
• [Journal Article] The replacement of the liver parenchyma in analbuminemic rats with allogenic hepatocytes is facilitated by intrabone marrow-bone marrow transplantation
  • Author(s): M.Inagaki, H.Furukawa, Y.Satake, Y.Okada, S.Ciba, N.Nishikawa, K.Ogawa
  • Journal Title: Cell Transplantation (in press)
• [Presentation] ラット同種肝細胞移植による宿主肝細胞置換につい-同種骨髄細胞移植による免疫寛容の誘導- (2010)
  • Author(s): 稲垣光裕、古川博之、西川祐司
  • Organizer: JDDW2010横浜
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 骨髄細胞移植した無アルブミンラットへのadult allogenic hepatocyte移植に関する検討 (2009)
  • Author(s): 稲垣光裕、佐竹由康、岡田陽子、葛西眞一、山本雅大、小川勝洋
  • Organizer: 第16回肝細胞研究会
  • Place of Presentation: 山形
  • Year and Date: 2009-06-26
• [Presentation] The effect of bone marrow and hepatocyte transplantation against retrorsine-partial hepatectomy induced liver injury in analbuminemic rats (2009)
  • Author(s): M.Inagaki, B.Zhang, J.Arikura, K.Ogawa
  • Organizer: The 10^<th> international cell transplant congress and 36^<th> annual meeting of JSOPMB (Symposium)
  • Place of Presentation: Okayama(Japan)
  • Year and Date: 2009-04-20