2010 Fiscal Year Final Research Report
Effects of selective bone marrow cells transplantation
| Project/Area Number |
20591509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
INAGAKI Mitsuhiro Asahikawa Medical College, 医学部, 非常勤講師 (80261410)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Katsuhiro 旭川医科大学, 医学部, 名誉教授 (50045514)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 移植外科学 |
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| Research Abstract |
The therapeutic effects of bone marrow and hepatocyte transplantation were investigated regarding the treatment of retrorsine-partial hepatectomy-induced liver injury. Analbuminemic F344alb rats were given 2 doses of retrorsine 2 wk apart, followed 4 wk later by transplantation with F344 rat bone marrow cells or hepatocytes immediately after a two-thirds hepatectomy. Both bone marrow and isolated hepatocytes transplantation into the liver could prevent acute hepatic injury, conceivably due to a paracrine mechanism.
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Research Products
(5 results)
