2010 Fiscal Year Final Research Report
Development of a method for simultaneous multiple thoracic and abdominal organ procurement using ET-Kyoto solution
| Project/Area Number |
20591522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
ZHAO Xiangdong Kyoto University, 大学院・医学研究科, 助教 (00444464)
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| Co-Investigator(Kenkyū-buntansha) |
FUJINAGA Takuji 京都大学, 大学院・医学研究科, 助教 (00444456)
CHEN Fengshi 京都大学, 大学院・医学研究科, 助教 (00452334)
BANDO Toru 京都大学, 大学院・医学研究科, 准教授 (20293954)
DATE Hiroshi 京都大学, 大学院・医学研究科, 教授 (60252962)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臓器保存 / 移植・再生医療 / トランスレーショナルリサーチ / 外科 |
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| Research Abstract |
Currently, different preservation solutions are utilized for the procurement and preservation of different organs. In the present study, a novel method was developed by using ET-Kyoto solution (ET-K) alone for multiple organs. Rat heart, kidney and small bowel transplantation models were established and the methods for flushing and procurement of both thoracic and abdominal organs were discussed. The efficacy of ET-K on kidney and heart preservation was evaluated using rat transplantation models. In the renal preservation, ET-K has shown superior to HTK and comparable to UW. In the cardiac preservation, the effect of ET-K was equal to that of HTK. Furthermore, the left ventricular function was well preserved by ET-K as evaluated with Langendorff rat heart perfusion model.
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[Journal Article] Comprehensive and innovative techniques for liver transplantation in rats : a surgical guide.2010
Author(s)
Hori T, Nguyen JH, Zhao X, Ogura Y, Hata T, Yagi S, Chen F, Baine AM, Ohashi N, Eckman CB, Herdt AR, Egawa H, Takada Y, Oike F, Sakamoto S, Kasahara M, Ogawa K, Hata K, Iida T, Yonekawa Y, Sibulesky L, Kuribayashi K, Kato T, Saito K, Wang L, Torii M, Sahara N, Kamo N, Sahara T, Yasutomi M, Uemoto S.
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Journal Title
World J Gastroenterol. 16(25)
Pages: 3120-3132
Peer Reviewed
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[Journal Article] Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation.2009
Author(s)
Yoshitomi M, Koshiba T, Haga H, Li Y, Zhao X, Cheng D, Miyagawa A, Sakashita H, Tsuruyama T, Ueda M, Okamoto S, Wood K, Sakaguchi S, Manabe T, Uemoto S.
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Journal Title
Transplantation 87(4)
Pages: 606-614
Peer Reviewed
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[Journal Article] Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury.2009
Author(s)
Zhang J, Chen F, Zhao X, Aoyama A, Okamoto T, Fujinaga T, Shoji T, Sakai H, Cui Y, Bando T, Date H.
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Journal Title
J Heart Lung Transplant. 28(1)
Pages: 79-84
Peer Reviewed
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[Journal Article] Successful sub-zero non-freezing preservation of rat lungs at -2 degrees C utilizing a new supercooling technology.2008
Author(s)
Okamoto T, Nakamura T, Zhang J, Aoyama A, Chen F, Fujinaga T, Shoji T, Hamakawa H, Sakai H, Manabe T, Wada H, Date H, Bando T.
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Journal Title
J Heart Lung Transplant. 27(10)
Pages: 1150-7
Peer Reviewed
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[Journal Article] Value of FOXP3 expression in peripheral blood as rejection marker after miniature swine lung transplantation.2008
Author(s)
Satoda N, Shoji T, Wu Y, Fijinaga T, Chen F, Aoyama A, Zhang J, Takahashi A, Okamoto T, Matsumoto I, Sakai H, Li Y, Zhao X, Manabe T, Kobayashi E, Sakaguchi S, Wada H, Uemoto S, Tottori J, Bando T, Date H, Koshiba T.
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Journal Title
J Heart Lung Transplant 27(12)
Pages: 1293-1301
Peer Reviewed
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