2010 Fiscal Year Final Research Report
Clarification of the molecular mechanism of Japanese triple negative breast cancers and the development of innovative therapy for them
| Project/Area Number |
20591549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TOKUNAGA Eriko Kyushu University, 大学病院, 学術研究員 (50325453)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOTANI Satoko 九州大学, 大学病院, 医員 (90419549)
OKI Eiji 九州大学, 医学研究院, 非常勤講師 (70380392)
SADANAGA Noriaki 九州大学, 医学研究院, 非常勤講師 (20304826)
OKADA Satoko 九州大学, 大学病院, 医員 (50546562)
AKIYOSHI Sayuri 九州大学, 大学病院, 医員 (50567360)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 乳癌 / トリプルネガティブ / basal-like / BRCA / FA経路 / cancer stem cell |
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| Research Abstract |
The lack of efficient treatment for triple negative breast cancers (TNBCs) results in their poor prognosis, and it is necessary to clarify the biological features and molecular mechanism of TNBCs in order to develop new efficient strategies. In this study, we investigated the relationships between TNBCs and abnormalities in BRCA/fanconi anemia (FA) pathway. The incidence and frequency of LOH was significantly higher in TN groups, and the incidence and frequency of LOH was increased as the nuclear grade was elevated. In the tumors with BRCA1 LOH, the incidence of LOH at tumor suppressor genes such as BRCA2, TP53, PTENwas higher and they were genetically unstable. The prognosis of the patients with tumors with BRCA1 LOH was significantly poor. There is a close correlation between TNBCs and abnormalities in BRCA/ FA pathway, and this pathway is considered important therapeutic targets for TNBCs.
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