2010 Fiscal Year Final Research Report
Experimental pancreatic cancer model using in vivo imaging system and its application
| Project/Area Number |
20591556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
UCHIDA Eiji Nippon Medical School, 大学院・医学研究科, 教授 (70176684)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 膵癌 / 実験モデル / イメージング |
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| Research Abstract |
We developed short-term pancreatic cancer transplantation models in hamsters using PGHAM-1-Luc, which is luciferase-positive PGHAM-1 cells. Administration of luciferin and usage of IVIS Imaging System could provide us with PGHAM-1 tumor imaging without sacrifice. This system might be useful not only for the research on tumor invasion and metastasis but also for the application to therapeutic trial with new substances. However, decrease of luciferase activity with culture passage is a problem to be solved.
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