2010 Fiscal Year Final Research Report
Basic and clinical study of new diagnostic method for gastrointestinal cancer using the ratio of free DNA fragments in the serum
| Project/Area Number |
20591558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Fujita Health University |
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Principal Investigator |
OZAWA Soji Fujita Health University, 医学部・消化器外科学, 教授 (10169287)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Tenzou 藤田保健衛生大学, 坂文種報徳會病院一般消化器外科, 講師 (00449464)
OOSHIMA Hisanori 藤田保健衛生大学, 坂文種報徳會病院一般消化器外科, 助教 (70367712)
ARAKAWA Satoshi 藤田保健衛生大学, 坂文種報徳會病院一般消化器外科, 助教
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| Project Period (FY) |
2008 – 2010
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| Keywords | 消化器癌 / DNA断片 / 悪性度診断法 |
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| Research Abstract |
The aim of this study was to analyze in the serum of nude mice that were implanted colorectal cancer cells and in the serum of colorectal cancer patients using Alu DNA sequences (Alu247 and Alu115) and to reveal whether Alu247/Alu115 ratio (Alu ratio) is related to outcome of treatments and to clinical-oncological factors. We concluded that the Alu ratio might be useful for predicting effects of chemotherapy and for discriminating between cancer and non-cancer. The Alu ratio was considered to have a higher discriminatory ability for diagnosing cancer than the CEA and CA19-9 tumor marker levels.
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