2010 Fiscal Year Final Research Report
Novel exploitation of hybrid-type armed oncolytic virus for scirrhous gastric cancer
| Project/Area Number |
20591574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
NAKAMORI Mikihito Wakayama Medical University, 医学部, 講師 (10322372)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
IWAHASHI Makoto 和歌山県立医科大学, 医学部, 講師 (70244738)
NAKAMURA Masaki 和歌山県立医科大学, 医学部, 助教 (80364090)
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| Project Period (FY) |
2008 – 2010
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| Keywords | スキルス胃癌 / ウイルス療法 / 腹膜播種 / 探索的研究 |
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| Research Abstract |
Scirrhous gastric cancer, a diffusely infiltrating type of poorly differentiated gastric cancer also known as linitis plastic-type cancer is characterized by rapid cancer cell infiltration. Therefore, scirrhous gastric cancer carries a worse prognosis than other types of gastric cancers. Viral therapy for scirrhous gastric cancer is a promising strategy. Viral therapy using herpes simplex virus-1 (HSV-1) is especially practical for clinical application when its safety and therapeutic potency are warranted. We have recently investigated arming oncolytic herpes virus engineered by taxane-mediated molecule.
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[Journal Article] Dendritic cells adenovirally-transduced with full-length mesothelin cDNA elicit mesothelin-specific cytotoxicity against pancreatic cancer cell lines in vitro.2011
Author(s)
Miyazawa M, Iwahashi M, Ojima T, Katsuda M, Nakamura M, Nakamori M, Ueda K, Naka T, Hayata K, Iida T, Yamaue H
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Journal Title
Cancer Lett. 305
Pages: 32-39
Peer Reviewed
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[Journal Article] Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer.2011
Author(s)
Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K, Nakamura Y, Yamaue H
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Journal Title
Oncol Rep. 25(5)
Pages: 1271-1277
Peer Reviewed
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[Journal Article] Clinicopathological characteristics of remnant gastric cancer after a distal gastrectomy.2010
Author(s)
Ojima T, Iwahashi M, 中森幹人, Nakamura M, Naka T, Katsuda M, Iida T, Tsuji T, Hayata K, Takifuji K, Yamaue H
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Journal Title
J Gastrointest Surg. 14(2)
Pages: 277-281
Peer Reviewed
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[Journal Article] Influence of overweight on patients with gastric cancer after undergoing curative gastrectomy : an analysis of 689 consecutive cases managed by a single center.2009
Author(s)
Ojima T, Iwahashi M, Nakamura M, Nakamura M, Naka T, Ishida K, Ueda K, Katsuda M, Iida T, Tsuji T, Yamaue H
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Journal Title
Arch Surg. 144(4)
Pages: 351-358
Peer Reviewed
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