2010 Fiscal Year Final Research Report
Mesenchymal stem cells infected with modified adenoviruses as carrier cells that target human gastrointestinal tumors
| Project/Area Number |
20591585
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Chiba Cancer Center (Research Institute) |
|---|
Principal Investigator |
TAGAWA Masatoshi Chiba Cancer Center (Research Institute), がん治療開発グループ, 部長 (20171572)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 食道がん / がん治療 / 遺伝子 / アデノウイルス / キャリアー細胞 |
|---|
| Research Abstract |
Majority of human solid tumors, when clinically in an advanced stage, is resistant to most of conventional therapies and consequently improved prognosis with a novel strategy is a crucial target in clinical settings. We developed type 5 adenoviruses which replicated preferentially within tumors and then examined the anti-tumor effects. We also modified the adenoviruses of which the receptor-binding site was replaced with that of type 35 adenoviruses, which subsequently increased the infectivity to human tumors due to a high receptor expression in the tumors. We examined a possible advantage to use carrier cells which were infected with such adenoviruses.
|
Research Products
(12 results)
-
[Journal Article] Combinatory cytotoxic effects produced by E1B-55kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma.2010
Author(s)
Ma G., Kawamura K., Li Q., Okamoto S., Suzuki N., Kobayashi H., Liang M., Tada Y., Tatsumi K., Hiroshima K., Shimada H., Tagawa M.
-
Journal Title
Cancer Gene Ther. 17
Pages: 803-813
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
