2010 Fiscal Year Final Research Report
Elucidation of mechanism of mesenchymal transition in HCC.
| Project/Area Number |
20591603
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
TAKAMURA Hiroyuki Kanazawa University, 附属病院, 助教 (40377396)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 肝臓外科学 |
|---|
| Research Abstract |
I clarified epithelial mesenchymal transition (EMT) which was transformation to treatment resistance to be often seen in local recurrence in the post-treatment (RFA and TACE) liver of the hepatocellular carcinoma (HCC). Furthermore I elucidated the molecular mechanism about EMT of HCC and clarified molecular target to prevent EMT with in vivo experimental model. It was probed that HIF-1 α has had extremely important role in EMT of the HCC and the EMT was restrained by using a repressor of HIF-1α such as valproic acid (VPA).
|
