2010 Fiscal Year Final Research Report
Isolation and characterization of murine hepatic stem cells (HPCs) based on a new surface antigen.
| Project/Area Number |
20591610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YASUCHIKA Kentaro Kyoto University, 医学研究科, 病院特定助教 (00378895)
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| Co-Investigator(Kenkyū-buntansha) |
IKAI Iwao 京都大学, 医学研究科, 非常勤講師 (60263084)
UEMOTO Shinji 京都大学, 医学研究科, 教授 (40252449)
KAMO Naoko 京都大学, 医学研究科, 医員 (50452355)
ISHII Takamichi 京都大学, 医学研究科, 医員 (70456789)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝幹細胞 / 表面抗原 / gp38 |
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| Research Abstract |
Previously, we clarified the surface antigen profiles of hepatic progenitor cells (HPCs) in fetal liver tissue as the CD49f+/CD45-/Thyl- cell fraction. In this study, we represented that more immature HPCs could be detected by using a novel surface antigen gp38 which was expressed in fetal livers but not in adult livers. Furthermore, the characterization of gp38-positive HPCs revealed that activation of Wnt signal pathway was related to the maintenance the undifferentiated state of HPCs.
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