The protective effect of percutaneous isolated hepatic perfusion on high-risk group for the recurrence of Hepatocellular carcinoma after resection

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kobe University
• Principal Investigator: KU Yonson Kobe University, 大学院・医学研究科, 教授 (40195615)
• Co-Investigator(Kenkyū-buntansha): FUKUMOTO Takumi 神戸大学, 大学院・医学研究科, 准教授 (70379402) ; KUSUNOKI Nobuya 神戸大学, 医学部付属病院, 准教授 (10379406) ; KIDO Masahiro 神戸大学, 医学部付属病院, 講師 (00403246)
• Project Period (FY): 2008 – 2010
• Keywords: 肝細胞癌 / 再発肝癌 / 経皮的肝灌流化学療法

Research Abstract

Hepatic resection remains the only therapeutic option for improved survival in the patients with hepatocellular carcinoma (HCC). However, a high incidence of recurrence after resection is life-threatening problem. In this study, we proposed percutaneous isolated hepatic perfusion (PIHP), a novel and potent regional chemotherapeutic regimen can achieve the protection against high-risk group for the recurrence of HCC after resection. PIHP after hepatic resection improved overall survival. In conclusion, dual treatment of resection and PIHP can offer an innovative strategy for resectable HCC treatment.

Research Products

• [Journal Article] Morphometric analysis of conformational changes in hepatic venous system after right lobe living donor liver transplantation. (2011)
  • Author(s): Takahashi M, Fukumoto T, Kido M, Tsuchida S, Takebe A, Kuramitsu K, Komatsu S, Hori Y, Ku Y.
  • Journal Title: Hepatol Res 41 Pages: 318-327
  • Peer Reviewed
• [Journal Article] Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes. (2011)
  • Author(s): Yokoyama K, Kaji H, He J, Tanaka C, Hazama R, Kamigaki T, Ku Y, Tohyama K, Tohyama Y.
  • Journal Title: J Biol Chem. 286 Pages: 5375-5382
  • Peer Reviewed
• [Journal Article] Effect of oxygenated perfluorocarbon on isolated islets during transportation. (2010)
  • Author(s): Terai S, Tsujimura T, Li S, Hori Y, Toyama H, Shinzeki M, Matsumoto I, Kuroda Y, Ku Y.
  • Journal Title: J Surg Res 162 Pages: 284-289
  • Peer Reviewed
• [Journal Article] Mucinous cystic neoplasm of the pancreas presenting with hemosuccus pancreaticus. (2010)
  • Author(s): Shinzeki M, Hori Y, Fujino Y, Matsumoto I, Toyama H, Tsujimura T, Sakai T, Ajiki T, Kuroda Y, Ku Y.
  • Journal Title: Surg Today 40 Pages: 470-473
  • Peer Reviewed
• [Journal Article] Surgical spacer placement and proton radiotherapy for unresectable hepatocellular carcinoma. (2010)
  • Author(s): Komatsu S, Hori Y, Fukumoto T, Murakami M, Hishikawa Y, Ku Y.
  • Journal Title: World J Gastroenterol 16 Pages: 1800-1803
  • Peer Reviewed
• [Journal Article] Novel assessment of hepatic iron distribution by synchrotron radiation X-ray fluorescence microscopy. (2010)
  • Author(s): Kinoshita H, Hori Y, Fukumoto T, Ohigashi T, Shinohara K, Hayashi Y, Ku Y.
  • Journal Title: Med Mol Morphol 43 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Particle beam radiotherapy with a surgical spacer placement for advanced abdominal leiomyosarcoma results in a significant clinical benefit. (2010)
  • Author(s): Fukumoto T, Komatsu S, Hori Y, Murakami M, Hishikawa Y, Ku Y.
  • Journal Title: J Surg Oncol. 101 Pages: 97-99
  • Peer Reviewed
• [Journal Article] The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. (2010)
  • Author(s): Mukubou H, Tsujimura T, Sasaki R, Ku Y.
  • Journal Title: Int J Oncol. 37 Pages: 821-828
  • Peer Reviewed
• [Journal Article] Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas. (2010)
  • Author(s): Mimura T, Masuda A, Matsumoto I, Shiomi H, Yoshida S, Sugimoto M, Sanuki T, Yoshida M, Fujita T, Kutsumi H, Ku Y, Azuma T.
  • Journal Title: J Clin Gastroenterol. 44 Pages: e224-229
  • Peer Reviewed
• [Journal Article] CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas. (2009)
  • Author(s): Shimizu K, Itoh T, Shimizu M, Ku Y, Hori Y.
  • Journal Title: Pancreas Pages: e207-e214
  • Peer Reviewed
• [Journal Article] Enhancement of anti-tumor immunity by high levels of Th1 and Th17 with a combination of dendritic cell fusion hybrids and regulatory T cell depletion in pancreatic cancer. (2009)
  • Author(s): Yamamoto M, Kamigaki T, Yamashita K, Hori Y, Hasegawa H, Kuroda D, Moriyama H, Nagata M, Ku Y, Kuroda Y.
  • Journal Title: Oncol Rep. 22 Pages: 337-343
  • Peer Reviewed
• [Journal Article] Atypical hemangioma mimicking hepatocellular carcinoma with a special note on radiological and pathological findings. (2009)
  • Author(s): Tsurusaki M, Kawasaki R, Yamaguchi M, Sugimoto K, Fukumoto T, Ku Y, Sugimura K.
  • Journal Title: Jpn J Radiol. 27 Pages: 156-160
  • Peer Reviewed
• [Journal Article] Plasma tissue factor pathway inhibitor levels in patients with acute pancreatitis. (2009)
  • Author(s): Yasuda T, Ueda T, Kamei K, Shinzaki W, Sawa H, Shinzeki M, Ku Y, Takeyama Y.
  • Journal Title: J Gastroenterol. 44 Pages: 1071-1079
  • Peer Reviewed
• [Journal Article] Resection of gallbladder cancer with hepatic metastasis after chemotherapy with gemcitabine. (2008)
  • Author(s): Morimoto H, Ajiki T, Takase S, Fujita T, Matsumoto T, Mita Y, Matsumoto I, Fujino Y, Suzuki Y, Kuroda Y, Ku Y.
  • Journal Title: J Hepatobiliary Pancreat Surg. 15 Pages: 655-658
  • Peer Reviewed
• [Journal Article] Diagnostic and prognostic value of peritoneal cytology in biliary tract cancer. (2008)
  • Author(s): Ajki T, Fujita T, Matsumoto I, Yasuda T, Fujino Y, Ueda T, Suzuki Y, Kuroda Y, Ku Y.
  • Journal Title: Hepatogastroenterology 55 Pages: 842-845
  • Peer Reviewed
• [Journal Article] Decreased expression of intestinal chemokine TECK/CCL25 in experimental obstructive jaundice and its reversal following internal biliary drainage. (2008)
  • Author(s): Matsumoto T, Ajiki T, Kajiwara E, Mita Y, Fujita T, Morimoto H, Miyazawa M, Ku Y.
  • Journal Title: J Gastroenterol. 43 Pages: 390-396
  • Peer Reviewed
• [Journal Article] Abdominal apparent diffusion coefficient measurements : effect of diffusion-weighted image quality and usefulness of anisotropic images. (2008)
  • Author(s): Yoshikawa T, Ohno Y, Kawamitsu H, Ku Y, Seo Y, Zamora CA, Aoyama N, Sugimura K.
  • Journal Title: Magn Reson Imaging 26 Pages: 1415-1420
  • Peer Reviewed
• [Journal Article] Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. (2008)
  • Author(s): Yasuda T, Takeyama Y, Ueda T, Shinzeki M, Sawa H, Takahiro N, Kamei K, Ku Y, Kuroda Y, Ohyanagi H.
  • Journal Title: Crit Care Med 36 Pages: 2048-2053
  • Peer Reviewed
• [Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma accompanied with inferior vena cava tumor thrombus.
  • Author(s): Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Ku Y, Murakami M.
  • Journal Title: J Gastroenterol in press.
  • Peer Reviewed
• [Journal Article] Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma.
  • Author(s): Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Sasaki R, Hori Y, Hishikawa Y, Ku Y, Murakami M.
  • Journal Title: Cancer in press.
  • Peer Reviewed
• [Journal Article] Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1a dependent manner in pancreatic cancer cells.
  • Author(s): Hashimoto O, Shimizu K, Semba S, Chiba S, Ku Y, Yokozaki H, Hori Y.
  • Journal Title: Pathobiology in press.
  • Peer Reviewed
• [Journal Article] A Focal Mass-Forming Autoimmune Pancreatitis mimicking pancreatic cancer with obstruction of the main pancreatic duct.
  • Author(s): Matsumoto I, Shinzeki M, Toyama H, Asari S, Goto T, Yamada I, Ajiki T, Fukumoto T, Ku Y.
  • Journal Title: J Gastrointest Surg. in press.
  • Peer Reviewed
• [Journal Article] Risk factors for survival and local recurrence after particle radiotherapy for single small hepatocellular carcinoma.
  • Author(s): Komatsu S, Murakami M, Fukumoto T, Hori Y, Hishikawa Y, Ku Y.
  • Journal Title: Br J Surg in press.
  • Peer Reviewed
• [Presentation] Hypoxia induces tumor aggressiveness by an acquired stem-like phenotype in pancreatic cancer through HIF1a signaling. (2010)
  • Author(s): 堀裕一, 他
  • Organizer: International Association of Pancreatology
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-07-11
• [Presentation] Usefulness of hand-assisted laparoscopic distal pancreatectomy. (2010)
  • Author(s): 松本逸平, 他
  • Organizer: International Association of Pancreatology
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-07-11
• [Presentation] Indication of laparoscopic distal pancreatectomy for the pancreatic neoplasms. (2010)
  • Author(s): 新関亮, 他
  • Organizer: International Association of Pancreatology
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-07-11
• [Presentation] Gemcitabineを中心とした化学療法と外科切除のcombinationを利用した進行胆道癌の治療戦略 (2010)
  • Author(s): 味木徹夫, 他
  • Organizer: 第22回日本肝胆膵外科学会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-05-26
• [Presentation] 当院におけるStage 1膵癌5例の検討 (2010)
  • Author(s): 白川幸代, 他
  • Organizer: 第22回日本肝胆膵外科学会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-05-26
• [Presentation] 粘液栓により膵頭部に急性膵炎を繰り返した膵尾部IPMNの1例 (2010)
  • Author(s): 松本逸平, 他
  • Organizer: 第22回日本肝胆膵外科学会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-05-26
• [Presentation] 胆道癌に対する減量切除と至適抗癌剤投与による治療戦略 (2010)
  • Author(s): 味木徹夫, 他
  • Organizer: 第96回日本消化器病学会
  • Place of Presentation: 新潟県民会館(新潟県)
  • Year and Date: 2010-04-22
• [Presentation] 両葉多発肝細胞癌に対する二段階治療 (2010)
  • Author(s): 木戸正浩, 他
  • Organizer: 第96回日本消化器病学会
  • Place of Presentation: 新潟県民会館(新潟県)
  • Year and Date: 2010-04-22
• [Presentation] 肝細胞癌治療における粒子線治療の位置づけ (2010)
  • Author(s): 小松昇平, 他
  • Organizer: 第101回日本外科学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2010-04-08
• [Presentation] 胆道癌におけるFDG-PETの意義と問題点 (2010)
  • Author(s): 山田勇, 他
  • Organizer: 第101回日本外科学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2010-04-08
• [Presentation] 癌幹細胞の関与からみた膵管癌とIPMNの分子病理学的鑑別診断 (2010)
  • Author(s): 堀裕一, 他
  • Organizer: 第101回日本外科学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2010-04-08
• [Presentation] 肝細胞癌アルゴリズムへの新しい提案 (2010)
  • Author(s): 木戸正浩, 他
  • Organizer: 第101回日本外科学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2010-04-08
• [Book] 外科 (2011)
  • Author(s): 松本逸平、白川幸代、福本巧、具英成
  • Total Pages: 187-196
  • Publisher: 南光堂
• [Book] 消化器疾患最新の治療 (2011)
  • Author(s): 松本逸平、具英成
  • Total Pages: 396-399
  • Publisher: 南光堂
• [Book] 膵臓 (2011)
  • Author(s): 松本逸平、新関亮、福本巧、具英成
  • Total Pages: 142-152
  • Publisher: 膵臓学会
• [Book] Digestive Surgery NOW (2010)
  • Author(s): 福本巧、冨永正寛、具英成
  • Total Pages: 126-137
  • Publisher: MEDICAL VIEW
• [Book] 手術 (2010)
  • Author(s): 土田忍、冨永正寛、岩崎武、具英成
  • Total Pages: 81-84
  • Publisher: 金原出版
• [Book] 消化器外科 (2010)
  • Author(s): 武部敦志、福本巧、木戸正浩、楠信也、岩崎武、冨永正寛、具英成
  • Total Pages: 63-71
  • Publisher: へるす出版
• [Book] 別冊日本臨床 (2010)
  • Author(s): 木下秘我、堀裕一、具英成
  • Total Pages: 175-177
  • Publisher: 日本臨床社
• [Book] 別冊日本臨床 (2010)
  • Author(s): 味木徹夫、具英成
  • Total Pages: 474-476
  • Publisher: 日本臨床社
• [Book] 膵臓の内視鏡外科手術 (2010)
  • Author(s): 松本逸平、新関亮、具英成
  • Total Pages: 54-61
  • Publisher: MEDICAL VIEW
• [Book] 肝胆膵 (2009)
  • Author(s): 福本巧、冨永正寛、具英成
  • Total Pages: 773-783
  • Publisher: アークメディア
• [Book] 手術 (2009)
  • Author(s): 福本巧、楠信也、木戸正浩、千堂義宏、高橋応典、具英成
  • Total Pages: 1761-1769
  • Publisher: 金原出版
• [Book] 外科 (2009)
  • Author(s): 村上昌雄、小松昇平、福本巧、具英成、菱川良夫
  • Total Pages: 587-593
  • Publisher: 南光堂
• [Book] 手術 (2008)
  • Author(s): 具英成、冨永正寛、福本巧
  • Total Pages: 1167-1174
  • Publisher: 金原出版
• [Book] 外科 (2008)
  • Author(s): 尾形哲、具英成
  • Total Pages: 1315-1318
  • Publisher: 南光堂
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/hbps/index.html