2010 Fiscal Year Final Research Report
Phase I study of HSP70 mRNA electroplorated denritic cells in patients with hepatocellular carcinoma
| Project/Area Number |
20591612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAMESA Takao Yamaguchi University, 医学部附属病院, 助教 (30359905)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝細胞癌 / mRNA導入樹状細胞療法 / エレクトロポレーション法 / 第I相試験 |
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| Research Abstract |
We conducted Phase I clinical trial of HSP70 mRNA-electroporated matured dendritic cells (DCs) in patients with hepatocellular carcinoma. A dose of DCs administrated subcutaneously 3 times every 3 weeks were escalated 1x10^7, 2x10^7, 3x10^7 cells. Ten patients were treated and had no serious events in this follow- up period. Two patients were CR. This treatment was safe and effective.
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