Analysis on invasion and metastasis of lung adenocarcinomas with micropapillary pattern.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kitasato University
• Principal Investigator: SATOH Yukitoshi Kitasato University, 医学部, 教授 (90321637)
• Co-Investigator(Kenkyū-buntansha): AMANO Hideki 北里大学, 医学部, 助教 (60296481) ; ISHIKAWA YUICHI (財)癌研究会, がん研究所, 部長 (80222975)
• Project Period (FY): 2008 – 2010
• Keywords: 肺癌 / 腺癌 / 微乳頭構造 / 免疫組織化学 / 血管新生因子

Research Abstract

To analyze the relationship between lung adenocarcinomas with micropapillary pattern (MPP) and vascular endothelial growth factors (VEGF), 517 cases of resected lung cancers were collected and clinic-pathologic study was performed. MPP- positive lung cancers revealed poor prognosis, frequent vascular invasion, and frequent lymph node metastasis. Immunohistochemically, VEGF-C and R3 strongly expressed in MPP portions. By the analysis on mice models, it was considered that VEGFR-1 and 2 plays an important role in tumor progression on the stromal tissue.

Research Products

• [Journal Article] Discriminant Model for Cytologic Distinction of Large Cell Neuroendocrine Carcinoma from Small Cell Carcinoma of the Lung (2010)
  • Author(s): Hoshi R, Furuta N, Horai T, Ishikawa Y, Miyata S, Satoh Y
  • Journal Title: J Thorac Oncol 5巻 Pages: 472-478
  • Peer Reviewed
• [Journal Article] Combined Effect of Anti-Angiogentic Agents, Angiotensin Type 1 Receptor Antagonists and Radiation Therapy. (2010)
  • Author(s): Amano H, Ohnuma Y, Niibe Y, Hayakawa K, Satoh Y, Majima M
  • Journal Title: Current Signal Transduction Therapy 5巻 Pages: 206-211
  • Peer Reviewed
• [Journal Article] Roles of a Prostaglandin E type Receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis (2009)
  • Author(s): Amano H, Ito Y, Suzuki T, Katoh S, Senior R, Kitasato H, Hayash I, Satoh Y, Narumiya S, Majima M
  • Journal Title: Cancer Sci 100巻 Pages: 2318-2324
  • Peer Reviewed
• [Journal Article] Association of Cytologic Micropapillary Clusters in Cytology Samples with Lymphatic Spread in Clinical Stage I Lung Adenocarcinomas (2009)
  • Author(s): Satoh Y, Hoshi R, Horai T, Okumura S, Nakagawa K, Ishikawa Y, Miyata S
  • Journal Title: Lung Cancer 64巻 Pages: 277-281
  • Peer Reviewed
• [Presentation] 原発性肺癌における細胞診での予後の推測に関する検討 (2010)
  • Author(s): 星利良,宝来威,文敏景,坂尾幸則,奥村栄,中川健,堀池篤,大柳文義,西尾誠人,元井紀子,石川雄一,宮田敏,佐藤之俊
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-11-03
• [Presentation] 特別講演 肺癌診療における呼吸器細胞診:現状と展望 (2010)
  • Author(s): 佐藤之俊
  • Organizer: 第27回日本臨床細胞学会北陸支部連合会学術集会
  • Place of Presentation: 福井
  • Year and Date: 2010-09-23
• [Presentation] Role of Angiotensin type 1a receptor signaling on tumor metastasis formation. (2010)
  • Author(s): Amano H, Ito Y,Matsui Y, Ogawa F, Kuroudu N, Nezu N, Iyoda A, Majima M, Satoh Y
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Angiogenesis enhanced by TP signaling- mediated platelet adhesion to neovasculized endothelial cells with VEGFR1+CXCR4 mobilization during hindlimb ischemia. (2010)
  • Author(s): Amano H, Kato S, Ito Y, Satoh Y, Majima M
  • Organizer: 9th World Congress for Microcirculation.
  • Place of Presentation: Paris
  • Year and Date: 2010-09-08
• [Presentation] Cytology of adenocarcinoma of the lung : peripheral non-invasive lesions and impact of micropapillary clusters on lung cancer treatment. (2010)
  • Author(s): Satoh Y, Hoshi R, Horai T, Okumura S, Nakagawa K, Ishikawa Y, Miyata S
  • Organizer: 17th International Congress of Cytology
  • Place of Presentation: Edinburgh, Scotland, UK
  • Year and Date: 2010-05-19
• [Book] 癌診療指針のための病理診断プラクティス 肺癌(青笹克之,松原修 編集)(細胞診断) (2011)
  • Author(s): 柿沼廣邦,佐藤之俊
  • Total Pages: 31-40
  • Publisher: 中山書店 東京
• [Book] 医用画像ハンドブック(石田隆行,桂川茂彦,藤田広志 監修 第9編 さまざまな医用画像.第8章 細胞診) (2010)
  • Author(s): 柿沼廣邦,佐藤之俊
  • Publisher: オーム社,東京