Research for producing the rapeutic agents on proteinkinase C to inhibit cerebral vasospasm following subarachnoid hemorrhage

2012 Fiscal Year Final Research Report

• Project/Area Number: 20591699
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: NISHIZAWA Shigeru 産業医科大学, 医学部, 教授 (40135257)
• Co-Investigator(Renkei-kenkyūsha): AKIBA Daisuke 産業医科大学, 医学部, 助教 (20441834) ; AOYAMA Yuichi 産業医科大学, 医学部, 助教 (50373155)
• Project Period (FY): 2008 – 2012
• Keywords: クモ膜下出血 / 脳血管攣縮 / 蛋白リン酸化酵素C / アイソフォーム / 創薬

Research Abstract

Cerebral vasospasm following subarachnoidhemorrhage(SAH)is an important factor to improve prognosis of the SAH patients. The mechanisms of cerebral vasospasm has still been unknown. PKCa and PKCd are most important candidates to produce cerebral vasospasm according to our own research results. The aim of this research is to search an inhibitor on both PKC isoforms and to produce therapeutic agents for inhibition of cerebral vasospasm. An inhibitor was found through the research, but production of therapeutic agent has no been available. Insertion of a catheter into subarachnoid space and continuous administration of the drug is considered to be a realistic way so far.

Research Products

• [Journal Article] The role of early brain injury in cerebral vasospasm following subarachnoid hemorrhage: From clinical and scientific aspects (2013)
  • Author(s): Nishizawa S
  • Journal Title: Acta Neurochir Volume: 115(suppl) Pages: 207-212
  • DOI: 10.1007/978-3-7091-1192-5_38
  • Peer Reviewed
• [Journal Article] Roles of signal transduciton mechanisms in cerebral vasospasm following subarahnoid hemorrhage: Overview (2011)
  • Author(s): Nishizawa S
  • Journal Title: Acta Neurochir Volume: 110(suppl) Pages: 27-34
  • DOI: 10.1007/978-3-7091-0353-1_5
  • Peer Reviewed
• [Presentation] The roles of signal transduction systems in pathophysiological mechanisnls of cerebral vasospasm - Overview- (2011)
  • Author(s): Nishizawa S
  • Organizer: 11th International Conference of Cerebral Vasospasm (Vasospasnl 2011)
  • Place of Presentation: Cincinnati, Ohio, USA
  • Year and Date: 20110000
• [Presentation] Vasospasm Biochemistry (2009)
  • Author(s): Nishizawa S
  • Organizer: 10th International Conference of Cerebral Vasospasm
  • Place of Presentation: Isutanbul Turkey
  • Year and Date: 20090000
• [Presentation] Treatment of vasospasm.-Scientific viewpoints to clinical use- (2009)
  • Author(s): Nishizawa S
  • Organizer: 10th International Conference of Cerebral Vasospasm
  • Place of Presentation: Isutanbul Turkey
  • Year and Date: 20090000
• [Book] Biochemical assessment of cerebral vasospasm: Measurement of cGMP, PKC, and PTR in cerebral arteries (2012)
  • Author(s): Koide M, Nishizawa S
  • Total Pages: 539-552
  • Publisher: Part VII Cerebral Vasospasm, in Animal Models of Acute Neurological Injuries II, (Edt:Chen J, Xu XM, Xu ZC, and Zhang J), Humana Press, USA