2010 Fiscal Year Final Research Report
Research on the differentiation mechanism of pituitary stem cells and its application to regeneration medicine
| Project/Area Number |
20591711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
HOJO Masato Kyoto University, 医学研究科, 講師 (60372588)
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| Co-Investigator(Kenkyū-buntansha) |
KAGEYAMA Ryoichiro 京都大学, ウイルス研究所, 教授 (80224369)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Nobuo 国立循環器病研究センター, 理事長 (40135570)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 下垂体 / Hes1 / Hes5 / マウス / 発生 / 前駆細胞 |
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| Research Abstract |
Hes genes are expressed by immature progenitor cells, but not differentiated hormonal cells in the developing mouse pituitary gland. Hes genes are essential for the maintenance of progenitors during the pituitary development. Hes genes control intermediate versus anterior lobe specification during the adenohypophysis development. Hes genes are also essential for the formation of neurohypophysis.
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