2010 Fiscal Year Final Research Report

Antiaging of intervertebral disc by controlling oxidative stress

Research Project

Project/Area Number	20591743
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Hiroshima University
Principal Investigator	TANAKA Nobuhiho Hiroshima University, 病院, 助教 (20363062)
Co-Investigator(Kenkyū-buntansha)	NAKANISHI Kazuyoshi 広島大学, 病院, 病院助教 (60403557) OCHI Mitsuo 広島大学, 病院, 教授 (70177244) MOCHIZUKI Yu 広島大学, 大学院・医歯薬学総合研究科, 准教授 (10284192)
Project Period (FY)	2008 – 2010
Keywords	老化 / 椎間板変性 / 酸化ストレス
Research Abstract	We studied to repress the progression of intervertebral disc degeneration using intervertebral disc degeneration model of Bach1deficient mice, which highly express Heme oxygenase-1 (HO-1) that is anti- oxidant material. To compared with Wild type mice, the histological progression of intevertebral disc degeneration was repressed in Bach1 deficient mice, and they highly expressed HO-1. The result showed that inhibiting oxidative stress can repress the progression of intervertebral disc degeneration, and new therapeutic method to intervertebral disc degeneration.

(3 results)