2010 Fiscal Year Final Research Report
Effects of volatile anesthetic(Sevoflurane) on cardiac rhythm and ion channels
| Project/Area Number |
20591796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
SUZUKI Akihiro Asahikawa Medical College, 医学部, 講師 (30292121)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 蘇生学 |
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| Research Abstract |
We electro-physiologically studied the effect of sevoflurane, a volatile anesthesthetic widely used in Japan, on transient outward K (Ito) channel and slow delayed rectifier K (IKs) channel using the patch clamp technique. Sevoflurane suppressed the Ito in a concentration dependent manner. Sevoflurane also suppressed the IKs transfected on HEK cell. Our result indicated that the sevoflurane prolongs action potential by suppressing these potassium channel and may have a similar effect as class III anti-arrythmia drugs.
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