2010 Fiscal Year Final Research Report
Treatment of ischemic neuronal damage by the preservation of mitochondrial membrane potential
| Project/Area Number |
20591804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Okayama University |
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Principal Investigator |
MORITA Kiyoshi Okayama University, 大学院・医歯薬学総合研究科, 教授 (40108171)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Yoshimasa 岡山大学, 岡山大学病院, 講師 (30294466)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 蘇生学 / ミトコンドリア / 脳虚血 |
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| Research Abstract |
The present research revealed following phenomenon.
1. Potassium channel opener decreases mitochondrial membrane potential to 51% of control level in rats (in vivo).
2. Concentration gradient of potassium is one of the most important factors that generate mitochondrial membrane potential.
3. Attenuation of mitochondrial potential does not activate glycolysis.
4. Attenuation of potassium gradient in mitochondria does not affect energy production in rat brain (in vivo).
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