2010 Fiscal Year Final Research Report
Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
| Project/Area Number |
20591829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
SAKAUE Gaku Osaka University, 医学系研究科, 助教 (70379254)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Takaya 大阪大学, 大学院・医学系研究科, 寄附講座助教 (00335358)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経障害性疼痛 / グリア |
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| Research Abstract |
Pro-inflammatory cytokines,generated from microglia or astrocyte, have been shown to be involved in the genesis, persistence, and severity of neuropathic pain following nerve injury. The transcription factor, NF-kappaB, plays a pivotal role in regulating pro-inflammatory cytokine gene expression. To elucidate the role of NF-kappaB in the pathogenesis of neuropathic pain, using a gene-based approach of NF-kappaB decoy, we tested whether the activated NF-kappaB affected pain behavior via the expression of inflammatory mediators.
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Research Products
(9 results)
