Transcriptional gene regulation in the sensory nerve during chronic pain status.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: AMAYA Fumimasa Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60347466)
• Co-Investigator(Kenkyū-buntansha): TANAKA Masaki 京都府立医科大学, 医学研究科, 准教授 (80264753) ; HASHIMOTO Satoru 京都府立医科大学, 医学研究科, 准教授 (90167578)
• Project Period (FY): 2008 – 2010
• Keywords: 痛覚過敏

Research Abstract

Expression of NF-IL6 and HMGB-1 was increased in the DRG in animal model of chronic pain. Inhibition of each of NF-IL6 or HMGB-1 alleviated pain hypersensitivity in chronic pain models suggesting that they are crucial for the development of chronic pain.

Research Products

• [Journal Article] Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury. (2010)
  • Author(s): Shibasaki M, Sasaki M, Miura M, Mizukoshi K, Ueno H, Hashimoto S, Tanaka Y, Amaya F.
  • Journal Title: Pain 149(3) Pages: 514-521
• [Journal Article] Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. (2009)
  • Author(s): Amaya F, Samad TA, Barrett L, Broom DC, Woolf CJ.
  • Journal Title: Pain 142(1-2) Pages: 59-67
• [Journal Article] Nociceptors are interleukin-1beta sensors. (2008)
  • Author(s): Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA.
  • Journal Title: J Neurosci. 24;28(52) Pages: 14062-14073
• [Journal Article] Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. (2008)
  • Author(s): Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ.
  • Journal Title: J Neurosci. 23;28(17) Pages: 4533-40
• [Presentation] 術後痛の基礎:末梢組織および一次知覚神経 (2010)
  • Author(s): 天谷文昌
  • Organizer: 日本ペインクリニック学会
  • Place of Presentation: 京都
  • Year and Date: 2010-07-10
• [Presentation] 局所麻酔薬の近未来:選択的Naチャネル阻害薬が拓く夢の鎮痛法 (2009)
  • Author(s): 天谷文昌
  • Organizer: 第56回日本麻酔科学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2009-08-17