2010 Fiscal Year Final Research Report
Comprehensive elucidation of estrogen receptor mediated signal pathways in hormone refractory prostate cancer
| Project/Area Number |
20591852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
KONAKA Hiroyuki Kanazawa University, 附属病院, 講師 (40334768)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOKAMI Atsushi 金沢大学, 附属病院, 講師 (50248580)
KYO Satoru 金沢大学, 医学系, 講師 (50272969)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前立腺癌 / エストロゲン受容体 / シグナル伝達 / 遺伝子治療 / SCIDマウス |
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| Research Abstract |
To reconsider a significance of Estrogen-based therapy in hormone refractory prostate cancer and elucidate a comprehensive mechanisms through which two type of Estrogen receptor, ERα and ERβ,can differently mediate signal transduction pathways. Consequently, our study made it clear that ERα might act as a pedal but ERβ as a brake in progression of prostate cancer, and also suggested the possibility of molecular targeting therapy for ERβ and gene therapy using ERβ expression vector and its ligand Estradiol.
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