2010 Fiscal Year Final Research Report
A study of chemoprevention of prostate cancer with statins in a knock-in mouse prostate cancer model
| Project/Area Number |
20591859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAKAI Hideki Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (40235122)
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| Co-Investigator(Kenkyū-buntansha) |
IGAWA Tsukasa 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (40295069)
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| Research Collaborator |
MIYATA Yasuyoshi 長崎大学, 病院, 講師 (60380888)
MARUTA Sugure 長崎大学, 大学院
WATANABE Shin-ichi 長崎大学, 大学院
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前立腺癌 / ノックインマウス / PSP94 / c-Fes |
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| Research Abstract |
Transrectal ultrasonography with an endovascular ultrasound probe allowed longitudinal monitoring of in situ tumor growth in the genetically engineered mouse prostate cancer model, PSP-KIMAP. Although preventative effects of statins in prostate cancer were not successfully analyzed, our data suggest that a non-receptor protein-tyrosine kinase, c-Fes may be involved in the development and progression of prostate cancer via cell proliferation. We speculate that c-Fes is a possible target in the treatment and chemoprevention of prostate cancer.
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