2010 Fiscal Year Final Research Report
Analysis of Molecular Mechanism of Congenital hydronephrosis.
| Project/Area Number |
20591874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
AOKI Yoshitaka University of Fukui, 医学部, 助教 (30273006)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hideaki 福井大学, 医学部, 助教 (00345620)
YOKOYAMA Osamu 福井大学, 医学部, 教授 (90242552)
YOKOTA Yoshifumi 福井大学, 医学部, 教授 (50222386)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 転写因子 / 腎盂尿管移行部狭窄 / 分化 / アンギオテンシン受容体 / SNP |
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| Research Abstract |
We recently showed that Id2 mutant mice develop hydronephrosis with congenital obstruction at the ureteropelvic junction, the characteristics of which show a close resemblance to those of human congenital hydronephrosis. We investigated whether Id2 was involved in the pathogenesis of hydronephrosis using unilateral ureteral obstruction (UUO) mouse model. After 3 days of UUO, Id2 gene expressions of renal pelvis were increased by 2.4-fold. Ingenuity pathway Analysis and microarray expression data analysis from public data database suggested that Id2 gene related with Angiotensinogen.
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[Journal Article] Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.2008
Author(s)
Gratze P, Dechend R, Stocker C, Park JK, Feldt S, Shagdarsuren E, Wellner M, Gueler F, Rong S, Gross V, Obst M, Plehm R, Alenina N, Zenclussen A, Titze J, Small K, Yokota Y, Zenke M, Luft FC, Muller DN
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Journal Title
Circulation 117(20)
Pages: 2645-2656
Peer Reviewed
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